Ebola virus: current and future perspectives
- PMID: 25910510
- DOI: 10.2174/1871526515666150320162259
Ebola virus: current and future perspectives
Abstract
The present outbreak associated with Ebola disease in Western countries of the African continent which is believed to be one of the massive eruptions caused by the Ebola viral infections. In the present scenario ebola has been transmitted to the European and American regions through the travelers from wide spread countries like Guinea, Liberia, Sierra Leone and Nigeria. The viral disease is spreading through the contact in any form by the infected persons or patients and creating huge risks to the mortals. The symptoms related to ebola virus are often highly pathogenic; about 70-80% of death cases are reported due to critical hemorrhagic fever. Early in infection, ebola virus infects macrophages and endothelial cells. It mainly produces a Viral Protein 24 (eVP24) which prevents interferon-based signals which are important for destruction of viruses. How ebola virus manipulates the function of the immune system is still unclear. Due to lack of this knowledge, no approved treatment is available. In this review, we have tried to compile the epidemiology, pathogenesis and treatment of ebola virus infection. The promising ligands against ebola virus have been also discussed which will be helpful for researchers to design drugs for the treatment of ebola virus disease.
Similar articles
-
Treatment of ebola virus disease.Pharmacotherapy. 2015 Jan;35(1):43-53. doi: 10.1002/phar.1545. Pharmacotherapy. 2015. PMID: 25630412 Review.
-
Ebola Virus: Pathogenesis and Countermeasure Development.Annu Rev Virol. 2019 Sep 29;6(1):435-458. doi: 10.1146/annurev-virology-092818-015708. Annu Rev Virol. 2019. PMID: 31567063 Review.
-
[Marburg and Ebola hemorrhagic fevers--pathogens, epidemiology and therapy].Med Monatsschr Pharm. 2014 Sep;37(9):324-30; quiz 331-2. Med Monatsschr Pharm. 2014. PMID: 25282746 Review. German.
-
Ebola virus disease - pathogenesis, clinical presentation and management.Folia Med Cracov. 2014;54(3):49-55. Folia Med Cracov. 2014. PMID: 25694095 Review.
-
Ebola Virus Altered Innate and Adaptive Immune Response Signalling Pathways: Implications for Novel Therapeutic Approaches.Infect Disord Drug Targets. 2016;16(2):79-94. doi: 10.2174/1871526516666160108114644. Infect Disord Drug Targets. 2016. PMID: 26743519 Review.
Cited by
-
Nanobiosensor-based diagnostic tools in viral infections: Special emphasis on Covid-19.Rev Med Virol. 2022 Mar;32(2):e2267. doi: 10.1002/rmv.2267. Epub 2021 Jun 23. Rev Med Virol. 2022. PMID: 34164867 Free PMC article. Review.
-
Impacts of Ebola disease outbreak in West Africa: Implications for government and public health preparedness and lessons from COVID-19.Sci Afr. 2023 Mar;19:e01513. doi: 10.1016/j.sciaf.2022.e01513. Epub 2022 Dec 17. Sci Afr. 2023. PMID: 36570591 Free PMC article.
-
Contrasting academic and lay press print coverage of the 2013-2016 Ebola Virus Disease outbreak.PLoS One. 2017 Jun 22;12(6):e0179356. doi: 10.1371/journal.pone.0179356. eCollection 2017. PLoS One. 2017. PMID: 28640889 Free PMC article.
-
Investigation of the psychological status of suspected patients during the Coronavirus disease 2019 epidemic.Medicine (Baltimore). 2020 Sep 18;99(38):e22260. doi: 10.1097/MD.0000000000022260. Medicine (Baltimore). 2020. PMID: 32957375 Free PMC article.
-
Education and Support for Healthcare Professionals to Prevent Future Pandemics: Report of a Conference Workshop.Ulster Med J. 2018 Oct;87(3):194-196. Epub 2018 Oct 1. Ulster Med J. 2018. PMID: 30559545 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
