Silybum marianum: Beyond Hepatoprotection
- PMID: 25686616
- DOI: 10.1177/2156587215571116
Silybum marianum: Beyond Hepatoprotection
Abstract
Silybum marianum is a medicinal plant that has long been used as hepatoprotective remedy. It has been used for the treatment of numerous liver disorders characterized by functional impairment or degenerative necrosis. Its hepatoprotective activity is unique and acts in different ways, including antioxidant and anti-inflammatory activities, cell permeability regulator and membrane stabilizer, stimulation of liver regeneration and inhibition of deposition in collagen fibers, which may lead to cirrhosis. Most of documented data with Silybum marianum are about liver disorders; however, recently several beneficial properties on a wide variety of other disorders such as renal protection, hypolipidemic and anti-atherosclerosis activities, cardiovascular protection, prevention of insulin resistance, especially in cirrhotic patients, cancer, and Alzheimer prevention. It is also used as a food remedy. This review article aims to present different aspects of Silybum marianum, especially the data in recently published articles about its effects on different diseases, apart from presenting the aspects of its hepatoprotection.
Keywords: Silybum marianum; Silymarin; antioxidant; hepatoprotective remedy.
© The Author(s) 2015.
Similar articles
-
A silychristin isomer and variation of flavonolignan levels in milk thistle (Silybum marianum) fruits.Planta Med. 2005 Sep;71(9):877-80. doi: 10.1055/s-2005-864187. Planta Med. 2005. PMID: 16206045
-
Milk thistle (Silybum marianum) for the therapy of liver disease.Am J Gastroenterol. 1998 Feb;93(2):139-43. doi: 10.1111/j.1572-0241.1998.00139.x. Am J Gastroenterol. 1998. PMID: 9468229 Review.
-
Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine.Indian J Med Res. 2006 Nov;124(5):491-504. Indian J Med Res. 2006. PMID: 17213517 Review.
-
Reassessing bioavailability of silymarin.Altern Med Rev. 2011 Sep;16(3):239-49. Altern Med Rev. 2011. PMID: 21951025 Review.
-
Milk thistle: Silybum marianum.Am J Health Syst Pharm. 1999 Jun 15;56(12):1195-7. doi: 10.1093/ajhp/56.12.1195. Am J Health Syst Pharm. 1999. PMID: 10484652 No abstract available.
Cited by
-
Effect of Silybum Marianum on Reduction of Chemotherapy-Induced Peripheral Neurotoxicity with Cisplatin.Adv Biomed Res. 2024 Mar 28;13:21. doi: 10.4103/abr.abr_365_21. eCollection 2024. Adv Biomed Res. 2024. PMID: 38808323 Free PMC article.
-
Natural feed additives and bioactive supplements versus chemical additives as a safe and practical approach to combat foodborne mycotoxicoses.Front Nutr. 2024 Feb 19;11:1335779. doi: 10.3389/fnut.2024.1335779. eCollection 2024. Front Nutr. 2024. PMID: 38450227 Free PMC article. Review.
-
Supplementation with Silybum marianum Extract, Synbiotics, Omega-3 Fatty Acids, Vitamins, and Minerals: Impact on Biochemical Markers and Fecal Microbiome in Overweight Dogs.Animals (Basel). 2024 Feb 9;14(4):579. doi: 10.3390/ani14040579. Animals (Basel). 2024. PMID: 38396547 Free PMC article.
-
Cheminformatics identification of modulators of key carbohydrate-metabolizing enzymes from C. cujete for type-2 diabetes mellitus intervention.J Diabetes Metab Disord. 2023 Jul 1;22(2):1299-1317. doi: 10.1007/s40200-023-01249-7. eCollection 2023 Dec. J Diabetes Metab Disord. 2023. PMID: 37969920 Free PMC article.
-
Silymarin Encapsulated Liposomal Formulation: An Effective Treatment Modality against Copper Toxicity Associated Liver Dysfunction and Neurobehavioral Abnormalities in Wistar Rats.Molecules. 2023 Feb 3;28(3):1514. doi: 10.3390/molecules28031514. Molecules. 2023. PMID: 36771180 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
