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. 2014 Dec;22(6):591-9.
doi: 10.1016/j.jsps.2014.02.007. Epub 2014 Feb 25.

Calcipotriol delivery into the skin as emulgel for effective permeation

V Naga Sravan Kumar Varma  1 , P V Maheshwari  1 , M Navya  1 , Sharath Chandra Reddy  1 , H G Shivakumar  1 , D V Gowda  1
Affiliations

Calcipotriol delivery into the skin as emulgel for effective permeation

V Naga Sravan Kumar Varma et al. Saudi Pharm J. 2014 Dec.

Abstract

The objective of this work is to formulate and evaluate an emulgel containing calcipotriol for treatment of psoriasis. Emulgels have emerged as a promising drug delivery system for the delivery of hydrophobic drugs. Isopropyl alcohol and polyethylene glycol have been employed as permeation enhancers. Formulation chart is made with seven formulations, evaluated for physical parameters, drug content, viscosity, thixotropy, spreadability, extrudability, mucoadhesion, diffusion studies, skin irritation test along with short term stability studies. Carbopolis is reported to have a direct influence on appearance and viscosity of final formulation. The photomicroscopic evaluations showed the presence of spherical globules in size range of 10-15 μm. Rheograms revealed that all the formulations exhibited pseudoplastic flow. Optimized formulation (F6) had shown 86.42 ± 2.0% drug release at the end of 8 h study. The release rate through dialysis membrane and rat skin is higher when compared to commercial calcipotriol ointment. Hence it is concluded that calcipotriol can be delivered topically with enhanced penetration properties when formulated as emulgel.

Keywords: Calcipotriol; Carbopol; Emulgel; PEG; Topical delivery.

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Figures

Figure 1
Figure 1
Schematic diagram illustrating bioadhesion measurement by the modified balance method (Navya et al., 2014).
Figure 2
Figure 2
Microphotograph of emulgel (magnification 40×).
Figure 3
Figure 3
Effect of shearing on viscosity of formulations F1–F7.
Figure 4
Figure 4
Rheograms of formulations F3–F7 and calcipotriol ointment.
Figure 5
Figure 5
Bioadhesive strength of emulgel formulations.
Figure 6
Figure 6
In vitro drug diffusion of API from formulations F3–F7 and calcipotriene ointment.
Figure 7
Figure 7
Release kinetics for calcipotriol ointment and F6 through rat skin.
Figure 8
Figure 8
Images showing the results of in vivo skin irritation test.
None
See this image and copyright information in PMC

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