Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

doi:10.1016/j.jalz.2014.10.008

Review

. 2015 Jun;11(6):710-7.

doi: 10.1016/j.jalz.2014.10.008. Epub 2014 Dec 12.

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

Heather M Snyder¹, Roderick A Corriveau², Suzanne Craft³, James E Faber⁴, Steven M Greenberg⁵, David Knopman⁶, Bruce T Lamb⁷, Thomas J Montine⁸, Maiken Nedergaard⁹, Chris B Schaffer¹⁰, Julie A Schneider¹¹, Cheryl Wellington¹², Donna M Wilcock¹³, Gregory J Zipfel¹⁴, Berislav Zlokovic¹⁵, Lisa J Bain¹⁶, Francesca Bosetti², Zorina S Galis¹⁷, Walter Koroshetz², Maria C Carrillo¹⁸

Affiliations

¹ Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA. Electronic address: hsnyder@alz.org.
² National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
³ Department of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
⁴ Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
⁵ Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁶ Department of Neurology, Mayo Clinic, Rochester, MN, USA.
⁷ Department of Neurosciences, Cleveland Clinic, Cleveland, OH, USA.
⁸ Department of Pathology, University of Washington, Seattle, WA, USA.
⁹ Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA.
¹⁰ Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
¹¹ Departments of Pathology and Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
¹² Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
¹³ Department of Physiology, University of Kentucky, Lexington, KY, USA.
¹⁴ Departments of Neurological Surgery and Neurology, Washington University, St Louis, St Louis, MO, USA.
¹⁵ Department of Physiology, University of Southern California, Los Angeles, CA, USA.
¹⁶ Independent Science Writer, Elverson, PA, USA.
¹⁷ National Institute of Heart, Lung and Blood, National Institutes of Health, Bethesda, MD, USA.
¹⁸ Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA.

PMID: 25510382
PMCID: PMC4731036
DOI: 10.1016/j.jalz.2014.10.008

Review

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

Heather M Snyder et al. Alzheimers Dement. 2015 Jun.

. 2015 Jun;11(6):710-7.

doi: 10.1016/j.jalz.2014.10.008. Epub 2014 Dec 12.

Authors

Affiliations

¹ Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA. Electronic address: hsnyder@alz.org.
² National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
³ Department of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
⁴ Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
⁵ Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁶ Department of Neurology, Mayo Clinic, Rochester, MN, USA.
⁷ Department of Neurosciences, Cleveland Clinic, Cleveland, OH, USA.
⁸ Department of Pathology, University of Washington, Seattle, WA, USA.
⁹ Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA.
¹⁰ Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
¹¹ Departments of Pathology and Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
¹² Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
¹³ Department of Physiology, University of Kentucky, Lexington, KY, USA.
¹⁴ Departments of Neurological Surgery and Neurology, Washington University, St Louis, St Louis, MO, USA.
¹⁵ Department of Physiology, University of Southern California, Los Angeles, CA, USA.
¹⁶ Independent Science Writer, Elverson, PA, USA.
¹⁷ National Institute of Heart, Lung and Blood, National Institutes of Health, Bethesda, MD, USA.
¹⁸ Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA.

PMID: 25510382
PMCID: PMC4731036
DOI: 10.1016/j.jalz.2014.10.008

Abstract

Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease. In December, 2013, the Alzheimer's Association, with scientific input from the National Institute of Neurological Disorders and Stroke and the National Heart, Lung and Blood Institute from the National Institutes of Health, convened scientific experts to discuss the research gaps in our understanding of how vascular factors contribute to Alzheimer's disease and related dementia. This manuscript summarizes the meeting and the resultant discussion, including an outline of next steps needed to move this area of research forward.

Keywords: Alzheimer's disease; Animal models; Biomarkers; Dementia; Small vessel disease; Vascular dementia.

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References

1. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(9):2672–713. - PMC - PubMed
1. Vickrey BG, Brott TG, Koroshetz WJ, et al. Stroke Research Priorities Meeting Steering C, the National Advisory Neurological D Stroke C. Research priority setting: a summary of the 2012 NINDS Stroke Planning Meeting Report. Stroke. 2013;44(8):2338–42. - PubMed
1. Montine TJ NINDS ADRD 2013 Commitee. Alzheimer’s Disease-Related Dementias: Research challenges and opportunities. Conference and recommendations report to the NINDS Council; Bethesda, Maryland: National Institute of Neurological Disorders and Stroke; 2013. [accessed online 1/22/14]. http://www.ninds.nih.gov/funding/areas/neurodegeneration/workshops/adrd2....
1. U.S. Department of Health and Human Services. [accessed 11/27/13];National Plan to Address Alzheimer’s Disease: 2013 Update. 2013 at http://aspe.hhs.gov/daltcp/napa/natlplan.shtml.
1. Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA. 1997;277(10):813–7. - PubMed

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[1] Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(9):2672–713. - PMC - PubMed

[2] Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(9):2672–713. - PMC - PubMed

[3] Vickrey BG, Brott TG, Koroshetz WJ, et al. Stroke Research Priorities Meeting Steering C, the National Advisory Neurological D Stroke C. Research priority setting: a summary of the 2012 NINDS Stroke Planning Meeting Report. Stroke. 2013;44(8):2338–42. - PubMed

[4] Vickrey BG, Brott TG, Koroshetz WJ, et al. Stroke Research Priorities Meeting Steering C, the National Advisory Neurological D Stroke C. Research priority setting: a summary of the 2012 NINDS Stroke Planning Meeting Report. Stroke. 2013;44(8):2338–42. - PubMed

[5] Montine TJ NINDS ADRD 2013 Commitee. Alzheimer’s Disease-Related Dementias: Research challenges and opportunities. Conference and recommendations report to the NINDS Council; Bethesda, Maryland: National Institute of Neurological Disorders and Stroke; 2013. [accessed online 1/22/14]. http://www.ninds.nih.gov/funding/areas/neurodegeneration/workshops/adrd2....

[6] Montine TJ NINDS ADRD 2013 Commitee. Alzheimer’s Disease-Related Dementias: Research challenges and opportunities. Conference and recommendations report to the NINDS Council; Bethesda, Maryland: National Institute of Neurological Disorders and Stroke; 2013. [accessed online 1/22/14]. http://www.ninds.nih.gov/funding/areas/neurodegeneration/workshops/adrd2....

[7] U.S. Department of Health and Human Services. [accessed 11/27/13];National Plan to Address Alzheimer’s Disease: 2013 Update. 2013 at http://aspe.hhs.gov/daltcp/napa/natlplan.shtml.

[8] U.S. Department of Health and Human Services. [accessed 11/27/13];National Plan to Address Alzheimer’s Disease: 2013 Update. 2013 at http://aspe.hhs.gov/daltcp/napa/natlplan.shtml.

[9] Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA. 1997;277(10):813–7. - PubMed

[10] Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA. 1997;277(10):813–7. - PubMed

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Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

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Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

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