Surface modification of multiwall carbon nanotubes determines the pro-inflammatory outcome in macrophage

doi:10.1016/j.jhazmat.2014.11.013

. 2015 Mar 2:284:73-82.

doi: 10.1016/j.jhazmat.2014.11.013. Epub 2014 Nov 15.

Surface modification of multiwall carbon nanotubes determines the pro-inflammatory outcome in macrophage

Ting Zhang¹, Meng Tang², Lu Kong³, Han Li⁴, Tao Zhang⁵, Yuying Xue⁶, Yuepu Pu⁷

Affiliations

¹ Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: zhangting1207@gmail.com.
² Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: tm@seu.edu.cn.
³ Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: kongluyaoyu@126.com.
⁴ Department of Material Science and Engineering, National Key Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210032, China. Electronic address: lihannju@gmail.com.
⁵ Department of Material Science and Engineering, National Key Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210032, China. Electronic address: ztnj@nju.edu.cn.
⁶ Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: yyxue@seu.edu.cn.
⁷ Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: yppu@seu.edu.cn.

PMID: 25463220
DOI: 10.1016/j.jhazmat.2014.11.013

Surface modification of multiwall carbon nanotubes determines the pro-inflammatory outcome in macrophage

Ting Zhang et al. J Hazard Mater. 2015.

. 2015 Mar 2:284:73-82.

doi: 10.1016/j.jhazmat.2014.11.013. Epub 2014 Nov 15.

Authors

Ting Zhang¹, Meng Tang², Lu Kong³, Han Li⁴, Tao Zhang⁵, Yuying Xue⁶, Yuepu Pu⁷

Affiliations

¹ Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: zhangting1207@gmail.com.
² Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: tm@seu.edu.cn.
³ Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: kongluyaoyu@126.com.
⁴ Department of Material Science and Engineering, National Key Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210032, China. Electronic address: lihannju@gmail.com.
⁵ Department of Material Science and Engineering, National Key Laboratory of Solid State Microstructures, Nanjing University, Nanjing 210032, China. Electronic address: ztnj@nju.edu.cn.
⁶ Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: yyxue@seu.edu.cn.
⁷ Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; Jiangsu key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China. Electronic address: yppu@seu.edu.cn.

PMID: 25463220
DOI: 10.1016/j.jhazmat.2014.11.013

Abstract

Carbon nanotubes (CNTs) are widely used in industry and biomedicine. While several studies have focused on biological matters, attempts to systematically elucidate the toxicity mechanisms of CNTs are limited. The aim of the present study was to evaluate and compare the cytotoxicity of raw multi-walled carbon nanotubes (MWCNTs) and MWCNTs functionalized with carboxylation (MWCNTs-COOH) or polyethylene glycol (MWCNTs-PEG) in murine macrophages. Our results show that only MWCNTs-COOH and raw MWCNTs alter the oxidative potential of macrophages by increasing reactive oxygen species and the expression of pro-inflammatory factors in both a concentration- and surface coating-dependent manner. The data suggest that compare with raw MWCNTs and MWCNTs-PEG, the MWCNTs-COOH produces a significant increase in ROS generation, interruption of ATP synthesis, and activation of the MAPK and NF-κB signaling pathways, which in turn upregulates IL-1β, IL-6, TNF-α, and iNOS to trigger cell death. These findings suggest that contributory cellar uptake caused by physicochemical factors rather than residual metal catalysts plays a role in ROS-mediated pro-inflammatory responses in vitro.

Keywords: Macrophages; Multi-walled carbon nanotubes; Pro-inflammatory; Surface-functionalized; Toxic mechanisms.

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Surface modification of multiwall carbon nanotubes determines the pro-inflammatory outcome in macrophage

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Surface modification of multiwall carbon nanotubes determines the pro-inflammatory outcome in macrophage

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