Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Nov 3;9(11):e107881.
doi: 10.1371/journal.pone.0107881. eCollection 2014.

Activation of markers of inflammation, coagulation and fibrinolysis in musculoskeletal trauma

Olav Reikerås  1 , Pål Borgen  2
Affiliations

Activation of markers of inflammation, coagulation and fibrinolysis in musculoskeletal trauma

Olav Reikerås et al. PLoS One. .

Abstract

Background: Traumatic injury induces changes in mediators of inflammation and coagulation, but the pivotal roles of inflammation and coagulation has not been precisely clarified. Therefore we have studied markers of inflammation and coagulation after a standardized musculoskeletal trauma like total hip replacement surgery.

Methods: We allocated 21 patients aged 50 to 84 years who underwent total hip replacement surgery. Releases of TNF-α, IL-1β, IL-6, IL-8 and IL-10 and protrombin fragment F1.2 and plasmin-antiplasmin complex (PAP) were examined during surgery and up 6 days postoperatively, and systemic releases were compared to pre-operative values. Surgery induced significant increments in serum levels of IL-6 at 6 hours and at 1 day after surgery and in levels of IL-8 at 6 hours after surgery. There were no significant changes in serum levels of TNF-α, IL-1β or IL-10. There were significant increments in blood levels of F1.2 and PAP up to 6 days postoperatively with highest levels at 6 hours after surgery. There were only week correlations between IL-6 and IL-8 and F1.2 and PAP.

Conclusion: Major musculoskeletal surgery causes changes of the inflammatory, coagulatory and fibrinolytic cascades in stable patients, but with no correlations between inflammation and coagulation and fibrinolysis.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Tidball JG (2005) Inflammatory processes in muscle injury and repair. Am J Physiol Regul Integr Comp Physiol 288: R345–353. - PubMed
    1. Rankin JA (2004) Biological mediators of acute inflammation. AACN Clin Issues15: 3–17. - PubMed
    1. Aird WC (2003) The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101: 3765–3777. - PubMed
    1. Esmon CT (2005) The interactions between inflammation and coagulation. Br J Haematol 131: 417–430. - PubMed
    1. Lee CC, Marill KA, Carter WA, Crupi RS (2001) A current concept of trauma-induced multiorgan failure. Ann Emerg Med 38: 170–176. - PubMed

Grants and funding

The authors have no support or funding to report.