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. 2014 Nov;20(11):1334-9.
doi: 10.1038/nm.3680. Epub 2014 Oct 19.

Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production

Elizabeth C Rosser  1 , Kristine Oleinika  1 , Silvia Tonon  2 , Ronan Doyle  3 , Anneleen Bosma  1 , Natalie A Carter  1 , Kathryn A Harris  4 , Simon A Jones  5 , Nigel Klein  3 , Claudia Mauri  1
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Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production

Elizabeth C Rosser et al. Nat Med. 2014 Nov.

Abstract

Regulatory B cells (Breg cells) differentiate in response to inflammation and subsequently restrain excessive immune responses via the release of interleukin-10 (IL-10). However, the precise inflammatory signals governing their differentiation remain to be elucidated. Here we show that the gut microbiota promotes the differentiation of Breg cells in the spleen as well as in the mesenteric lymph nodes. Perturbation of the gut microbiome imposed either by antibiotic treatment or by changes in the sterility of housing conditions reduces the number and function of Breg cells. Following the induction of arthritis, IL-1β and IL-6 are produced only in conventionally housed mice and both cytokines directly promote Breg cell differentiation and IL-10 production. Mice lacking IL-6 receptor (IL-6R) or IL-1 receptor 1 (IL-1R1) specifically on B cells have a reduced number of IL-10-producing B cells and develop exacerbated arthritis compared to control animals. Thus, in response to inflammatory signals induced by both the gut flora and arthritis, Breg cells increase in number and restrain excessive inflammation.

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References

    1. J Clin Invest. 2011 Nov;121(11):4268-80 - PubMed
    1. J Immunol. 2011 May 15;186(10):5569-79 - PubMed
    1. J Immunol. 2011 Sep 15;187(6):3402-12 - PubMed
    1. Appl Environ Microbiol. 2007 Aug;73(16):5261-7 - PubMed
    1. Bioinformatics. 2010 Oct 1;26(19):2460-1 - PubMed

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