Abdominal candidiasis is a hidden reservoir of echinocandin resistance

doi:10.1128/AAC.04134-14

. 2014 Dec;58(12):7601-5.

doi: 10.1128/AAC.04134-14. Epub 2014 Oct 6.

Abdominal candidiasis is a hidden reservoir of echinocandin resistance

Ryan K Shields¹, M Hong Nguyen², Ellen G Press³, Cornelius J Clancy⁴

Affiliations

¹ Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
² Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA mhn5@pitt.edu.
³ Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
⁴ Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.

PMID: 25288081
PMCID: PMC4249510
DOI: 10.1128/AAC.04134-14

Abdominal candidiasis is a hidden reservoir of echinocandin resistance

Ryan K Shields et al. Antimicrob Agents Chemother. 2014 Dec.

. 2014 Dec;58(12):7601-5.

doi: 10.1128/AAC.04134-14. Epub 2014 Oct 6.

Authors

Ryan K Shields¹, M Hong Nguyen², Ellen G Press³, Cornelius J Clancy⁴

Affiliations

¹ Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
² Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA mhn5@pitt.edu.
³ Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
⁴ Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.

PMID: 25288081
PMCID: PMC4249510
DOI: 10.1128/AAC.04134-14

Abstract

FKS mutant Candida isolates were recovered from 24% (6/25) of abdominal candidiasis patients exposed to echinocandin. Candida glabrata (29%) and Candida albicans (14%) mutants were identified. Multidrug-resistant bacteria were recovered from 83% of FKS mutant infections. Mutations were associated with prolonged echinocandin exposure (P = 0.01), breakthrough infections (P = 0.03), and therapeutic failures despite source control interventions (100%). Abdominal candidiasis is a hidden reservoir for the emergence of echinocandin-resistant Candida.

PubMed Disclaimer

Cited by

Update on Antifungal Drug Resistance.
Perlin DS, Shor E, Zhao Y. Perlin DS, et al. Curr Clin Microbiol Rep. 2015 Jun 1;2(2):84-95. doi: 10.1007/s40588-015-0015-1. Curr Clin Microbiol Rep. 2015. PMID: 26120512 Free PMC article.
Resistance to Echinocandins Complicates a Case of Candida albicans Bloodstream Infection: A Case Report.
Trovato L, Bongiorno D, Calvo M, Migliorisi G, Boraccino A, Musso N, Oliveri S, Stefani S, Scalia G. Trovato L, et al. J Fungi (Basel). 2021 May 21;7(6):405. doi: 10.3390/jof7060405. J Fungi (Basel). 2021. PMID: 34064200 Free PMC article.
Rezafungin Versus Caspofungin in a Phase 2, Randomized, Double-blind Study for the Treatment of Candidemia and Invasive Candidiasis: The STRIVE Trial.
Thompson GR, Soriano A, Skoutelis A, Vazquez JA, Honore PM, Horcajada JP, Spapen H, Bassetti M, Ostrosky-Zeichner L, Das AF, Viani RM, Sandison T, Pappas PG. Thompson GR, et al. Clin Infect Dis. 2021 Dec 6;73(11):e3647-e3655. doi: 10.1093/cid/ciaa1380. Clin Infect Dis. 2021. PMID: 32955088 Free PMC article. Clinical Trial.
Invasive Fungal Infections after Liver Transplantation.
Senoner T, Breitkopf R, Treml B, Rajsic S. Senoner T, et al. J Clin Med. 2023 Apr 30;12(9):3238. doi: 10.3390/jcm12093238. J Clin Med. 2023. PMID: 37176678 Free PMC article. Review.
Echinocandin Resistance in Candida Species: a Review of Recent Developments.
Wiederhold NP. Wiederhold NP. Curr Infect Dis Rep. 2016 Dec;18(12):42. doi: 10.1007/s11908-016-0549-2. Curr Infect Dis Rep. 2016. PMID: 27771864 Review.

See all "Cited by" articles

References

1. Andes DR, Safdar N, Baddley JW, Playford G, Reboli AC, Rex JH, Sobel JD, Pappas PG, Kullberg BJ. 2012. Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials. Clin. Infect. Dis. 54:1110–1122. 10.1093/cid/cis021. - DOI - PubMed
1. Shields RK, Nguyen MH, Press EG, Kwa AL, Cheng S, Du C, Clancy CJ. 2012. The presence of an FKS mutation rather than MIC is an independent risk factor for failure of echinocandin therapy among patients with invasive candidiasis due to Candida glabrata. Antimicrob. Agents Chemother. 56:4862–4869. 10.1128/AAC.00027-12. - DOI - PMC - PubMed
1. Alexander BD, Johnson MD, Pfeiffer CD, Jimenez-Ortigosa C, Catania J, Booker R, Castanheira M, Messer SA, Perlin DS, Pfaller MA. 2013. Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations. Clin. Infect. Dis. 56:1724–1732. 10.1093/cid/cit136. - DOI - PMC - PubMed
1. Beyda ND, John J, Kilic A, Alam MJ, Lasco TM, Garey KW. 2014. FKS mutant Candida glabrata: risk factors and outcomes in patients with candidemia. Clin. Infect. Dis. 59:819–825. 10.1093/cid/ciu407. - DOI - PubMed
1. Carneiro HA, Mavrakis A, Mylonakis E. 2011. Candida peritonitis: an update on the latest research and treatments. World J. Surg. 35:2650–2659. 10.1007/s00268-011-1305-2. - DOI - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

[1] Andes DR, Safdar N, Baddley JW, Playford G, Reboli AC, Rex JH, Sobel JD, Pappas PG, Kullberg BJ. 2012. Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials. Clin. Infect. Dis. 54:1110–1122. 10.1093/cid/cis021. - DOI - PubMed

[2] Andes DR, Safdar N, Baddley JW, Playford G, Reboli AC, Rex JH, Sobel JD, Pappas PG, Kullberg BJ. 2012. Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials. Clin. Infect. Dis. 54:1110–1122. 10.1093/cid/cis021. - DOI - PubMed

[3] Shields RK, Nguyen MH, Press EG, Kwa AL, Cheng S, Du C, Clancy CJ. 2012. The presence of an FKS mutation rather than MIC is an independent risk factor for failure of echinocandin therapy among patients with invasive candidiasis due to Candida glabrata. Antimicrob. Agents Chemother. 56:4862–4869. 10.1128/AAC.00027-12. - DOI - PMC - PubMed

[4] Shields RK, Nguyen MH, Press EG, Kwa AL, Cheng S, Du C, Clancy CJ. 2012. The presence of an FKS mutation rather than MIC is an independent risk factor for failure of echinocandin therapy among patients with invasive candidiasis due to Candida glabrata. Antimicrob. Agents Chemother. 56:4862–4869. 10.1128/AAC.00027-12. - DOI - PMC - PubMed

[5] Alexander BD, Johnson MD, Pfeiffer CD, Jimenez-Ortigosa C, Catania J, Booker R, Castanheira M, Messer SA, Perlin DS, Pfaller MA. 2013. Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations. Clin. Infect. Dis. 56:1724–1732. 10.1093/cid/cit136. - DOI - PMC - PubMed

[6] Alexander BD, Johnson MD, Pfeiffer CD, Jimenez-Ortigosa C, Catania J, Booker R, Castanheira M, Messer SA, Perlin DS, Pfaller MA. 2013. Increasing echinocandin resistance in Candida glabrata: clinical failure correlates with presence of FKS mutations and elevated minimum inhibitory concentrations. Clin. Infect. Dis. 56:1724–1732. 10.1093/cid/cit136. - DOI - PMC - PubMed

[7] Beyda ND, John J, Kilic A, Alam MJ, Lasco TM, Garey KW. 2014. FKS mutant Candida glabrata: risk factors and outcomes in patients with candidemia. Clin. Infect. Dis. 59:819–825. 10.1093/cid/ciu407. - DOI - PubMed

[8] Beyda ND, John J, Kilic A, Alam MJ, Lasco TM, Garey KW. 2014. FKS mutant Candida glabrata: risk factors and outcomes in patients with candidemia. Clin. Infect. Dis. 59:819–825. 10.1093/cid/ciu407. - DOI - PubMed

[9] Carneiro HA, Mavrakis A, Mylonakis E. 2011. Candida peritonitis: an update on the latest research and treatments. World J. Surg. 35:2650–2659. 10.1007/s00268-011-1305-2. - DOI - PubMed

[10] Carneiro HA, Mavrakis A, Mylonakis E. 2011. Candida peritonitis: an update on the latest research and treatments. World J. Surg. 35:2650–2659. 10.1007/s00268-011-1305-2. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Abdominal candidiasis is a hidden reservoir of echinocandin resistance

Affiliations

Abdominal candidiasis is a hidden reservoir of echinocandin resistance

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical