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Review
. 2014 Dec;28(4):633-50.
doi: 10.1016/j.idc.2014.08.007. Epub 2014 Sep 30.

Finding a cure for human immunodeficiency virus-1 infection

Joel N Blankson  1 , Janet D Siliciano  1 , Robert F Siliciano  2
Affiliations
Review

Finding a cure for human immunodeficiency virus-1 infection

Joel N Blankson et al. Infect Dis Clin North Am. 2014 Dec.

Abstract

Remarkable advances have been made in the treatment of human immunodeficiency virus (HIV)-1 infection, but in the entire history of the epidemic, only 1 patient has been cured. Herein we review the fundamental mechanisms that render HIV-1 infection difficult to cure and then discuss recent clinical and experimental situations in which some form of cure has been achieved. Finally, we consider approaches that are currently being taken to develop a general cure for HIV-1 infection.

Keywords: Antiretroviral therapy; Cure; HIV; Latent reservoir; Retroviral persistence.

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References

    1. Sheehy AM, Gaddis NC, Choi JD, Malim MH. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral vif protein. Nature. 2002;418:646–650. - PubMed
    1. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature. 1995;373:123–126. - PubMed
    1. Wei X, Ghosh SK, Taylor ME, et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature. 1995;373:117–122. - PubMed
    1. Piatak M, Jr, Saag MS, Yang LC, et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science. 1993;259:1749–1754. - PubMed
    1. Rabi SA, Laird GM, Durand CM, et al. Multi-step inhibition explains HIV-1 protease inhibitor pharmacodynamics and resistance. J Clin Invest. 2013 In press. - PMC - PubMed

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