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Review
. 2014 Jun;13(6):433-44.
doi: 10.1038/nrd4280. Epub 2014 May 16.

Liver X receptors in lipid metabolism: opportunities for drug discovery

Cynthia Hong  1 , Peter Tontonoz  1
Affiliations
Review

Liver X receptors in lipid metabolism: opportunities for drug discovery

Cynthia Hong et al. Nat Rev Drug Discov. 2014 Jun.

Abstract

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These transcription factors control the expression of a battery of genes involved in the uptake, transport, efflux and excretion of cholesterol in a tissue-dependent manner. The identification of the LXRs, and an increased understanding of the mechanisms by which LXR signalling regulates lipid homeostasis in different tissues (including the liver, intestine and brain), has highlighted new opportunities for therapeutic intervention in human metabolism. New strategies for the pharmacological manipulation of LXRs and their target genes offer promise for the treatment of human diseases in which lipids have a central role, including atherosclerosis and Alzheimer's disease.

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