doi: 10.1016/j.cell.2014.01.044.
Epub 2014 Feb 20.
Neurogenesis in the striatum of the adult human brain
Affiliations
- PMID: 24561062
- DOI: 10.1016/j.cell.2014.01.044
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Neurogenesis in the striatum of the adult human brain
Cell.
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Free article
Abstract
In most mammals, neurons are added throughout life in the hippocampus and olfactory bulb. One area where neuroblasts that give rise to adult-born neurons are generated is the lateral ventricle wall of the brain. We show, using histological and carbon-14 dating approaches, that in adult humans new neurons integrate in the striatum, which is adjacent to this neurogenic niche. The neuronal turnover in the striatum appears restricted to interneurons, and postnatally generated striatal neurons are preferentially depleted in patients with Huntington's disease. Our findings demonstrate a unique pattern of neurogenesis in the adult human brain.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment in
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Off the beaten track: new neurons in the adult human striatum.Cell. 2014 Feb 27;156(5):870-1. doi: 10.1016/j.cell.2014.02.027. Cell. 2014. PMID: 24581487
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Neurogenesis: a striatal supply of new neurons.Nat Rev Neurosci. 2014 Apr;15(4):203. doi: 10.1038/nrn3714. Epub 2014 Mar 5. Nat Rev Neurosci. 2014. PMID: 24594987 No abstract available.
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