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. 2014 Feb;157(2):464-469.e1.
doi: 10.1016/j.ajo.2013.09.026. Epub 2013 Sep 29.

Increased risk of Parkinson disease following a diagnosis of neovascular age-related macular degeneration: a retrospective cohort study

Shiu-Dong Chung  1 , Jau-Der Ho  2 , Chao-Chien Hu  3 , Herng-Ching Lin  4 , Jau-Jiuan Sheu  5
Affiliations

Increased risk of Parkinson disease following a diagnosis of neovascular age-related macular degeneration: a retrospective cohort study

Shiu-Dong Chung et al. Am J Ophthalmol. 2014 Feb.

Abstract

Purpose: To investigate the risk for Parkinson disease during a 3-year follow-up period after a diagnosis of neovascular age-related macular degeneration (AMD) using a nationwide population-based dataset in Taiwan.

Design: A retrospective matched-cohort study.

Methods: We identified 877subjects with neovascular AMD as the study cohort and randomly selected 8770 subjects for a comparison cohort. Each subject was individually followed for a 3-year period to identify those who subsequently developed Parkinson disease. Stratified Cox proportional hazard regressions were performed as a means of comparing the 3-year risk of subsequent Parkinson disease between the study and comparison cohorts.

Results: The incidence rate of Parkinson disease was 5.32 (95% confidence interval [CI]: 3.03-8.72) per 1000 person-years in patients with neovascular AMD and 2.09 (95% CI: 1.59-2.70) per 1000 person-years in comparison patients. The log-rank test indicated that subjects with neovascular AMD had a significantly lower 3-year Parkinson disease-free survival rate than comparison subjects (P < .001). After censoring cases in which patients died during the follow-up period and adjusting for monthly income, geographic region, hypertension, diabetes, hyperlipidemia, and coronary heart disease, the hazard ratio of Parkinson disease during the 3-year follow-up period for subjects with neovascular AMD was 2.57 (95% CI: 1.42-4.64) that of comparison subjects.

Conclusion: In this study, subjects with neovascular AMD were found to be at a significant risk of Parkinson disease during a 3-year follow-up period after their diagnosis among Taiwanese Chinese. Further study is needed to confirm our findings and explore the underlying pathomechanism.

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