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Review
. 2013 Sep 21;5(18):8307-8325.
doi: 10.1039/c3nr01525d.

Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation

Anil Kumar #  1   2 , Fei Chen #  1   2 , Anbu Mozhi  1   2 , Xu Zhang  1 , Yuanyuan Zhao  1 , Xiangdong Xue  1   2 , Yanli Hao  3 , Xiaoning Zhang  3 , Paul C Wang  4 , Xing-Jie Liang  1
Affiliations
Review

Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation

Anil Kumar et al. Nanoscale. .

Abstract

The advent of nanotechnology has reignited interest in the field of pharmaceutical science for the development of nanomedicine. Nanomedicinal formulations are nanometer-sized carrier materials designed for increasing the drug tissue bioavailability, thereby improving the treatment of systemically applied chemotherapeutic drugs. Nanomedicine is a new approach to deliver the pharmaceuticals through different routes of administration with safer and more effective therapies compared to conventional methods. To date, various kinds of nanomaterials have been developed over the years to make delivery systems more effective for the treatment of various diseases. Even though nanomaterials have significant advantages due to their unique nanoscale properties, there are still significant challenges in the improvement and development of nanoformulations with composites and other materials. Here in this review, we highlight the nanomedicinal formulations aiming to improve the balance between the efficacy and the toxicity of therapeutic interventions through different routes of administration and how to design nanomedicine for safer and more effective ways to improve the treatment quality. We also emphasize the environmental and health prospects of nanomaterials for human health care.

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Figures

Fig. 1
Fig. 1
Schematic diagram for the future-nanorriedicine production system.
Fig. 2
Fig. 2
Important routes of nanopartide based drug administration.
Fig. 3
Fig. 3
Nanoformulations used as transdermal drug delivery systems.
Fig. 4
Fig. 4
Systemic delivery of free drugs and nanocarrier systems Through the barriers of transderrnal drug delivery.
Fig. 5
Fig. 5
The image represents the regional deposition of particles within the lungs, depending on the particles size and the overall inhalation process.
Fig. 6
Fig. 6
Different factors influence on the pulmonary delivery ot drug and nanoparticle sysiems
Fig. 7
Fig. 7
A simplified depiction of potential factors that may influence the effects of engineered nanoparticles on the health system.
Fig. 8
Fig. 8
Different parameters for the selection of nanocarriers tor the formulation process.
Fig. 9
Fig. 9
(a) Nanomedical global sales by therapeutic area, 2009–2016; (source: BCC Research) (b) projected contributions in the field of nanomedicine or pharmaceutical fields for human health care, according to the US economy, 2015 (source: US Science Foundation, 2003).
See this image and copyright information in PMC

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