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. 2013;4(8):662-4.
doi: 10.1016/j.ijscr.2013.04.034. Epub 2013 May 13.

Lactobacillus fermentum, a pathogen in documented cholecystitis

Josue Chery  1 , Dmitriy Dvoskin, Fernando P Morato, Bashar Fahoum
Affiliations

Lactobacillus fermentum, a pathogen in documented cholecystitis

Josue Chery et al. Int J Surg Case Rep. 2013.

Abstract

Introduction: Lactobacillus species are probiotics proven to exhibit various preventative as well as therapeutic properties. While lactobacillus species have been implicated in the formation of dental caries, endocarditis and bacteremia, their role as pathogens in cholecystitis has not been reported. We present a rare case of Lactobacillus fermentum working as a pathogen in cholecystitis.

Presentation of case: An 81-year old male was admitted with right upper quadrant abdominal pain. His signs, symptoms, laboratory values and imaging were consistent with a diagnosis of cholecystitis with ascending cholangitis. In view of his co-morbidity and severe sepsis, the patient was treated non-operatively with antibiotics and cholecystostomy. L. fermentum, which was vancomycin resistant, was identified from the cholecystostomy aspirate and from anaerobic blood culture. The patient went into septic shock, developed multi-organ dysfunction syndrome and eventually died.

Discussion: Commensal bacteria such as L. fermentum are known to modulate immunity, reduce the pathogenicity of gastrointestinal organisms and play a therapeutic role in various disease processes. We isolated L. fermentum as a pathogen in a documented case of cholecystitis with ascending cholangitis.

Conclusion: While the routine use lactobacillus species as a probiotic is supported in the literature, understanding its potential role as a pathogen may allow more judicious use of these bacteria and encourage research to elucidate the pathogenicity of lactobacillus species.

Keywords: Cholangitis; Cholecystitis; Lactobacillus; Multi-organ dysfunction syndrome; Pathogenicity; Probiotic.

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