Lessons learned from lung cancer genomics: the emerging concept of individualized diagnostics and treatment
- PMID: 23589544
- DOI: 10.1200/JCO.2012.45.9867
Lessons learned from lung cancer genomics: the emerging concept of individualized diagnostics and treatment
Abstract
The advent of novel therapeutics that specifically target signaling pathways activated by genetic alterations has revolutionized the way patients with lung cancer are treated. Although only few and largely ineffective chemotherapeutic regimens were available 10 years ago, a lung tumor diagnosed today requires extensive pathologic subtyping and diagnosis of genome alterations to afford more effective treatment (eg, in EGFR-mutant adenocarcinoma). This change of paradigm has several profound implications, ranging from preclinical work on the mechanism of action to a novel, more biologically oriented taxonomy and from genome diagnostics to trial design. Here, we have summarized these developments into six conceptual paradigms that illustrate the transition from empirical cancer medicine to mechanistically based individualized oncology.
Similar articles
-
Precision oncology: an overview.J Clin Oncol. 2013 May 20;31(15):1803-5. doi: 10.1200/JCO.2013.49.4799. Epub 2013 Apr 15. J Clin Oncol. 2013. PMID: 23589545 No abstract available.
-
Genomics driven-oncology: challenges and perspectives.BMC Cancer. 2015 Mar 23;15:141. doi: 10.1186/s12885-015-1147-7. BMC Cancer. 2015. PMID: 25884512 Free PMC article. Review.
-
Genomic medicine frontier in human solid tumors: prospects and challenges.J Clin Oncol. 2013 May 20;31(15):1874-84. doi: 10.1200/JCO.2012.45.2268. Epub 2013 Apr 15. J Clin Oncol. 2013. PMID: 23589551 Review.
-
Oncologists push beyond new lung cancer genomic testing guidelines.J Natl Cancer Inst. 2015 Feb 12;107(2):djv023. doi: 10.1093/jnci/djv023. Print 2015 Feb. J Natl Cancer Inst. 2015. PMID: 25677038 No abstract available.
-
Genetic basis for susceptibility to lung cancer: Recent progress and future directions.Adv Cancer Res. 2010;109:51-72. doi: 10.1016/B978-0-12-380890-5.00002-8. Adv Cancer Res. 2010. PMID: 21070914 Review.
Cited by
-
Evaluation of Lung Cancer Patient Response to First-Line Chemotherapy by Integration of Tumor Core Biopsy Metabolomics with Multiscale Modeling.Ann Biomed Eng. 2023 Apr;51(4):820-832. doi: 10.1007/s10439-022-03096-8. Epub 2022 Oct 12. Ann Biomed Eng. 2023. PMID: 36224485 Free PMC article.
-
Histone methylation modification patterns and relevant M-RiskScore in acute myeloid leukemia.Heliyon. 2022 Sep 16;8(9):e10610. doi: 10.1016/j.heliyon.2022.e10610. eCollection 2022 Sep. Heliyon. 2022. PMID: 36164519 Free PMC article.
-
Accuracy of endoscopic ultrasound-guided needle aspiration specimens for molecular diagnosis of non-small-cell lung carcinoma.World J Clin Cases. 2020 Nov 6;8(21):5139-5148. doi: 10.12998/wjcc.v8.i21.5139. World J Clin Cases. 2020. PMID: 33269250 Free PMC article.
-
Radiomics: an overview in lung cancer management-a narrative review.Ann Transl Med. 2020 Sep;8(18):1191. doi: 10.21037/atm-20-4589. Ann Transl Med. 2020. PMID: 33241040 Free PMC article. Review.
-
Clinicoradiopathological features and prognosis according to genomic alterations in patients with resected lung adenocarcinoma.J Thorac Dis. 2020 Oct;12(10):5357-5368. doi: 10.21037/jtd-20-1716. J Thorac Dis. 2020. PMID: 33209369 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous