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Controlled Clinical Trial
. 2013 Jul;70(1):45-53.
doi: 10.1111/aji.12117. Epub 2013 Apr 1.

Serum proinflammatory cytokine responses to influenza virus vaccine among women during pregnancy versus non-pregnancy

Lisa M Christian  1 , Kyle Porter, Erik Karlsson, Stacey Schultz-Cherry, Jay D Iams
Affiliations
Controlled Clinical Trial

Serum proinflammatory cytokine responses to influenza virus vaccine among women during pregnancy versus non-pregnancy

Lisa M Christian et al. Am J Reprod Immunol. 2013 Jul.

Abstract

Objective: This study aimed to comprehensively describe inflammatory responses to trivalent influenza virus vaccine (TIV) among pregnant women and determine whether responses differ compared to non-pregnancy.

Methods: Twenty-eight pregnant and 28 non-pregnant women were vaccinated. Serum cytokines were measured at baseline, and 1, 2, and 3 days post-vaccination. Anti-influenza antibody titers were measured at baseline and 1 month post-vaccination.

Results: Overall, following vaccination, tumor necrosis factor (TNF)-α and interleukin(IL)-6 increased significantly, peaking at 1 day post-vaccination (P's < 0.001). Pregnant versus non-pregnant women showed no differences in IL-6, TNF-α, or IL-1β responses. Pregnant women showed no change in IL-8 and increases in migration inhibitory factor (MIF), while non-pregnant showed decreases in both. Pregnancy did not significantly alter antibody responses.

Conclusions: Inflammatory responses to TIV are mild, transient, and generally similar in pregnant and non-pregnant women. Given the variability evidenced, vaccination may provide a useful model for studying individual differences in inflammatory response propensity.

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Figures

Fig 1-5
Fig 1-5
Serum proinflammatory cytokine responses to trivalent influenza virus vaccine (TIV)
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References

    1. Fofie AE, Fewell JE, Moore SL. Pregnancy influences the plasma cytokine response to intraperitoneal administration of bacterial endotoxin in rats. Exp Physiol. 2004;90:95–101. - PubMed
    1. Aguilar-Valles A, Poole S, Mistry Y, Williams S, Luheshi GN. Attenuated fever in rats during late pregnancy is linked to suppressed interieukin-6 production after localized inflammation with turpentine. Journal of Physiology-London. 2007;583:391–403. - PMC - PubMed
    1. Ashdown H, Poole S, Boksa P, Luheshi GN. Interleukin-1 receptor antagonist as a modulator of gender differences in the febrile response to lipopolysaccharide in rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 2007;292:R1667–R1674. - PubMed
    1. Elenkov IJ, Wilder RL, Bakalov VK, Link AA, Dimitrov MA, Fisher S, Crane M, Kanik KS, Chrousos GP. IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: Implications for autoimmune disease activity during these times. J Clin Endocrinol Metab. 2001;86:4933–4938. - PubMed
    1. Marzi M, Vigano A, Trabattoni D, Villa ML, Salvaggio A, Clerici E, Clerici M. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin Exp Immunol. 1996;106:127–133. - PMC - PubMed

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