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Review
. 2013 Feb;13(2):97-110.
doi: 10.1038/nrc3447.

Regulatory networks defining EMT during cancer initiation and progression

Bram De Craene  1 , Geert Berx
Affiliations
Review

Regulatory networks defining EMT during cancer initiation and progression

Bram De Craene et al. Nat Rev Cancer. 2013 Feb.

Abstract

Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during development, but is an unintentional behaviour of cells during cancer progression. The EMT-associated reprogramming of cells not only suggests that fundamental changes may occur to several regulatory networks but also that an intimate interplay exists between them. Disturbance of a controlled epithelial balance is triggered by altering several layers of regulation, including the transcriptional and translational machinery, expression of non-coding RNAs, alternative splicing and protein stability.

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References

    1. Oncogene. 2013 Jan 17;32(3):277-85 - PubMed
    1. EMBO Rep. 2008 Jun;9(6):582-9 - PubMed
    1. Nat Med. 2011 Aug 07;17(9):1101-8 - PubMed
    1. J Biol Chem. 2008 Jun 27;283(26):18344-54 - PubMed
    1. Biochim Biophys Acta. 2003 Apr 1;1611(1-2):16-30 - PubMed

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