How cancer metabolism is tuned for proliferation and vulnerable to disruption

doi:10.1038/nature11706

Review

. 2012 Nov 15;491(7424):364-73.

doi: 10.1038/nature11706.

How cancer metabolism is tuned for proliferation and vulnerable to disruption

Almut Schulze¹, Adrian L Harris

Affiliations

Affiliation

¹ Gene Expression Analysis Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. almut.schulze@cancer.org.uk

PMID: 23151579
DOI: 10.1038/nature11706

Review

How cancer metabolism is tuned for proliferation and vulnerable to disruption

Almut Schulze et al. Nature. 2012.

. 2012 Nov 15;491(7424):364-73.

doi: 10.1038/nature11706.

Authors

Almut Schulze¹, Adrian L Harris

Affiliation

¹ Gene Expression Analysis Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. almut.schulze@cancer.org.uk

PMID: 23151579
DOI: 10.1038/nature11706

Erratum in

Nature. 2013 Feb 7;494(7435):130

Abstract

Cancer metabolism has received a substantial amount of interest over the past decade. The advances in analytical tools have, along with the rapid progress of cancer genomics, generated an increasingly complex understanding of metabolic reprogramming in cancer. As numerous connections between oncogenic signalling pathways and metabolic activities emerge, the importance of metabolic reprogramming in cancer is being increasingly recognized. The identification of metabolic weaknesses of cancer cells has been used to create strategies for treating cancer, but there are still challenges to be faced in bringing the drugs that target cancer metabolism to the clinic.

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References

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[1] J Pathol. 2012 Jun;227(2):146-56 - PubMed

[2] J Pathol. 2012 Jun;227(2):146-56 - PubMed

[3] EMBO Rep. 2011 May;12(5):463-9 - PubMed

[4] EMBO Rep. 2011 May;12(5):463-9 - PubMed

[5] J Cell Mol Med. 2010 Apr;14(4):771-94 - PubMed

[6] J Cell Mol Med. 2010 Apr;14(4):771-94 - PubMed

[7] Science. 1956 Feb 24;123(3191):309-14 - PubMed

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[9] Proc Natl Acad Sci U S A. 2012 May 1;109(18):6904-9 - PubMed

[10] Proc Natl Acad Sci U S A. 2012 May 1;109(18):6904-9 - PubMed

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How cancer metabolism is tuned for proliferation and vulnerable to disruption

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How cancer metabolism is tuned for proliferation and vulnerable to disruption

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Erratum in

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