Acute inflammation initiates the regenerative response in the adult zebrafish brain
- PMID: 23138980
- DOI: 10.1126/science.1228773
Acute inflammation initiates the regenerative response in the adult zebrafish brain
Abstract
The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we showed that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified cysteinyl leukotriene signaling as an essential component of inflammation in the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish, in contrast to mammals, inflammation is a positive regulator of neuronal regeneration in the central nervous system.
Comment in
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Neuroscience. Inflammation to rebuild a brain.Science. 2012 Dec 7;338(6112):1303-4. doi: 10.1126/science.1232331. Science. 2012. PMID: 23224546 Free PMC article. No abstract available.
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Utilizing neuro-inflammation: turning degeneration to regeneration.CNS Neurol Disord Drug Targets. 2012 Dec;11(8):953-4. doi: 10.2174/1871527311211080002. CNS Neurol Disord Drug Targets. 2012. PMID: 23244421 No abstract available.
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