Acute inflammation initiates the regenerative response in the adult zebrafish brain
- PMID: 23138980
- DOI: 10.1126/science.1228773
Acute inflammation initiates the regenerative response in the adult zebrafish brain
Abstract
The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we showed that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified cysteinyl leukotriene signaling as an essential component of inflammation in the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish, in contrast to mammals, inflammation is a positive regulator of neuronal regeneration in the central nervous system.
Comment in
-
Neuroscience. Inflammation to rebuild a brain.Science. 2012 Dec 7;338(6112):1303-4. doi: 10.1126/science.1232331. Science. 2012. PMID: 23224546 Free PMC article. No abstract available.
-
Utilizing neuro-inflammation: turning degeneration to regeneration.CNS Neurol Disord Drug Targets. 2012 Dec;11(8):953-4. doi: 10.2174/1871527311211080002. CNS Neurol Disord Drug Targets. 2012. PMID: 23244421 No abstract available.
Similar articles
-
Regenerative neurogenesis from neural progenitor cells requires injury-induced expression of Gata3.Dev Cell. 2012 Dec 11;23(6):1230-7. doi: 10.1016/j.devcel.2012.10.014. Epub 2012 Nov 15. Dev Cell. 2012. PMID: 23168169
-
Adult neurogenesis and brain regeneration in zebrafish.Dev Neurobiol. 2012 Mar;72(3):429-61. doi: 10.1002/dneu.20918. Dev Neurobiol. 2012. PMID: 21595047 Review.
-
Neuroscience. Inflammation to rebuild a brain.Science. 2012 Dec 7;338(6112):1303-4. doi: 10.1126/science.1232331. Science. 2012. PMID: 23224546 Free PMC article. No abstract available.
-
Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors.Development. 2011 Nov;138(22):4831-41. doi: 10.1242/dev.072587. Epub 2011 Oct 17. Development. 2011. PMID: 22007133
-
Endogenous neurogenesis following ischaemic brain injury: insights for therapeutic strategies.Int J Biochem Cell Biol. 2014 Nov;56:4-19. doi: 10.1016/j.biocel.2014.08.003. Epub 2014 Aug 14. Int J Biochem Cell Biol. 2014. PMID: 25128862 Review.
Cited by
-
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair.Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. doi: 10.1038/nrm3619. Epub 2013 Jul 10. Nat Rev Mol Cell Biol. 2013. PMID: 23839576 Free PMC article. Review.
-
Key miRNAs associated with memory and learning disorder upon exposure to sevoflurane determined by RNA sequencing.Mol Med Rep. 2020 Aug;22(2):1567-1575. doi: 10.3892/mmr.2020.11199. Epub 2020 Jun 1. Mol Med Rep. 2020. PMID: 32626949 Free PMC article.
-
Neurogenesis in zebrafish - from embryo to adult.Neural Dev. 2013 Feb 21;8:3. doi: 10.1186/1749-8104-8-3. Neural Dev. 2013. PMID: 23433260 Free PMC article. Review.
-
Differential requirement for irf8 in formation of embryonic and adult macrophages in zebrafish.PLoS One. 2015 Jan 23;10(1):e0117513. doi: 10.1371/journal.pone.0117513. eCollection 2015. PLoS One. 2015. PMID: 25615614 Free PMC article.
-
Regenerative neurogenesis: the integration of developmental, physiological and immune signals.Development. 2022 Apr 15;149(8):dev199907. doi: 10.1242/dev.199907. Epub 2022 May 3. Development. 2022. PMID: 35502778 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases