Phosphatidylcholine biosynthesis and function in bacteria
- PMID: 22922101
- DOI: 10.1016/j.bbalip.2012.08.009
Phosphatidylcholine biosynthesis and function in bacteria
Abstract
Phosphatidylcholine (PC) is the major membrane-forming phospholipid in eukaryotes and is estimated to be present in about 15% of the domain Bacteria. Usually, PC can be synthesized in bacteria by either of two pathways, the phospholipid N-methylation (Pmt) pathway or the phosphatidylcholine synthase (Pcs) pathway. The three subsequent enzymatic methylations of phosphatidylethanolamine are performed by a single phospholipid N-methyltransferase in some bacteria whereas other bacteria possess multiple phospholipid N-methyltransferases each one performing one or several distinct methylation steps. Phosphatidylcholine synthase condenses choline directly with CDP-diacylglycerol to form CMP and PC. Like in eukaryotes, bacterial PC also functions as a biosynthetic intermediate during the formation of other biomolecules such as choline, diacylglycerol, or diacylglycerol-based phosphorus-free membrane lipids. Bacterial PC may serve as a specific recognition molecule but it affects the physicochemical properties of bacterial membranes as well. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.
Copyright © 2012 Elsevier B.V. All rights reserved.
Similar articles
-
Plant-exuded choline is used for rhizobial membrane lipid biosynthesis by phosphatidylcholine synthase.J Biol Chem. 1999 Jul 9;274(28):20011-6. doi: 10.1074/jbc.274.28.20011. J Biol Chem. 1999. PMID: 10391951
-
Pathways for phosphatidylcholine biosynthesis in bacteria.Microbiology (Reading). 2003 Dec;149(Pt 12):3461-3471. doi: 10.1099/mic.0.26522-0. Microbiology (Reading). 2003. PMID: 14663079
-
Biosynthesis of phosphatidylcholine in bacteria.Prog Lipid Res. 2003 Mar;42(2):115-62. doi: 10.1016/s0163-7827(02)00050-4. Prog Lipid Res. 2003. PMID: 12547654 Review.
-
Expression and physiological relevance of Agrobacterium tumefaciens phosphatidylcholine biosynthesis genes.J Bacteriol. 2009 Jan;191(1):365-74. doi: 10.1128/JB.01183-08. Epub 2008 Oct 31. J Bacteriol. 2009. PMID: 18978052 Free PMC article.
-
Novel pathway for phosphatidylcholine biosynthesis in bacteria associated with eukaryotes.J Biotechnol. 2001 Oct 4;91(2-3):211-21. doi: 10.1016/s0168-1656(01)00331-5. J Biotechnol. 2001. PMID: 11566392 Review.
Cited by
-
Homeostasis and catabolism of choline and glycine betaine: lessons from Pseudomonas aeruginosa.Appl Environ Microbiol. 2013 Apr;79(7):2112-20. doi: 10.1128/AEM.03565-12. Epub 2013 Jan 25. Appl Environ Microbiol. 2013. PMID: 23354714 Free PMC article. Review.
-
Choline Supplementation Sensitizes Legionella dumoffii to Galleria mellonella Apolipophorin III.Int J Mol Sci. 2020 Aug 13;21(16):5818. doi: 10.3390/ijms21165818. Int J Mol Sci. 2020. PMID: 32823647 Free PMC article.
-
Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans.Nat Commun. 2024 Feb 19;15(1):1520. doi: 10.1038/s41467-024-45782-2. Nat Commun. 2024. PMID: 38374083 Free PMC article.
-
Metabolic Responses of "Big Six" Escherichia coli in Wheat Flour to Thermal Treatment Revealed by Nuclear Magnetic Resonance Spectroscopy.Appl Environ Microbiol. 2022 Apr 12;88(7):e0009822. doi: 10.1128/aem.00098-22. Epub 2022 Mar 14. Appl Environ Microbiol. 2022. PMID: 35285244 Free PMC article.
-
Streptococcus mitis and S. oralis Lack a Requirement for CdsA, the Enzyme Required for Synthesis of Major Membrane Phospholipids in Bacteria.Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02552-16. doi: 10.1128/AAC.02552-16. Print 2017 May. Antimicrob Agents Chemother. 2017. PMID: 28223392 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
