Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Mar;30 Suppl(Suppl):S19-25.
doi: 10.1016/j.bbi.2012.06.005. Epub 2012 Jun 21.

Neuroendocrine influences on cancer progression

Guillermo N Armaiz-Pena  1 , Steve W Cole, Susan K Lutgendorf, Anil K Sood
Affiliations
Review

Neuroendocrine influences on cancer progression

Guillermo N Armaiz-Pena et al. Brain Behav Immun. 2013 Mar.

Abstract

During the past decade, new studies have continued to shed light on the role of neuroendocrine regulation of downstream physiological and biological pathways relevant to cancer growth and progression. More specifically, our knowledge of the effects of the sympathetic nervous system (SNS) on cancer biology has been greatly expanded by new data demonstrating how the cellular immune response, inflammatory processes, tumor-associated angiogenesis, and tumor cell invasion and survival converge to promote tumor growth. This review will summarize these studies, while synthesizing clinical, cellular and molecular research that has continued to unearth the biological events mediating the interplay between SNS-related processes and cancer progression.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Overview of catecholamine-mediated signaling pathways in cancer
Norepinephrine (NE) or Epinephrine (Epi) bind to beta adrenergic receptors (ADRB), resulting in increased cyclic AMP (cAMP) levels that induce Protein Kinase A (PKA) activity. PKA can then phosphorylate several proteins, such as CREB/ATF, GATA1 and Src leading to increased activity of several pro-tumoral proteins. Additionally, elevated levels of cAMP also result in the activation of Exchange Protein Activated by cAMP (EPAC) and its associated signaling cascade. Conversely, upon binding to dopamine receptor 2 (DR2), Dopamine (DA) can inhibit Adenylyl cyclase (AC) function leading to decreased cAMP and downstream pro-tumoral protein levels.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Aguado LI, Ojeda SR. Prepubertal ovarian function is finely regulated by direct adrenergic influences. Role of noradrenergic innervation. Endocrinology. 1984;114:1845–1853. - PubMed
    1. Algazi M, Plu-Bureau G, Flahault A, Dondon MG, Le MG. Could treatments with beta-blockers be associated with a reduction in cancer risk? Rev Epidemiol Sante Publique. 2004;52:53–65. - PubMed
    1. Andersen BL, Farrar WB, Golden-Kreutz D, Kutz LA, MacCallum R, Courtney ME, Glaser R. Stress and immune responses after surgical treatment for regional breast cancer. J Natl Cancer Inst. 1998;90:30–36. - PMC - PubMed
    1. Andersen BL, Thornton LM, Shapiro CL, Farrar WB, Mundy BL, Yang HC, Carson WE., 3rd Biobehavioral, immune, and health benefits following recurrence for psychological intervention participants. Clinical cancer research: an official journal of the American Association for Cancer Research. 2010;16:3270–3278. - PMC - PubMed
    1. Andersen BL, Yang HC, Farrar WB, Golden-Kreutz DM, Emery CF, Thornton LM, Young DC, Carson WE., 3rd Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial. Cancer. 2008;113:3450–3458. - PMC - PubMed

Publication types

MeSH terms