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Review
. 2012 May;96(3):475-96, ix-x.
doi: 10.1016/j.mcna.2012.04.003. Epub 2012 May 1.

Immunotherapies in rheumatologic disorders

Anne V Miller  1 , Sriya K M Ranatunga
Affiliations
Review

Immunotherapies in rheumatologic disorders

Anne V Miller et al. Med Clin North Am. 2012 May.

Abstract

Over the past several decades, rheumatology has directed its focus to understanding and countering the immune dysregulation underlying autoimmune diseases with rheumatologic manifestations. Older therapies, effective though poorly understood, are being scrutinized anew and are yielding the immune-modulating mechanisms behind their efficacy. New therapies, the "biologics," are drugs tailored to address specific immune defects and imbalances. This article discusses the current standard and biologic immunotherapies of the rheumatic diseases, correlating our current understanding of their mechanisms with dysfunctions believed to be present in the major autoimmune syndromes, especially rheumatoid arthritis and systemic lupus erythematosus.

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