Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Jan 24;12(2):89-103.
doi: 10.1038/nrc3205.

Targeting MET in cancer: rationale and progress

Ermanno Gherardi  1 , Walter Birchmeier, Carmen Birchmeier, George Vande Woude
Affiliations
Review

Targeting MET in cancer: rationale and progress

Ermanno Gherardi et al. Nat Rev Cancer. .

Erratum in

  • Nat Rev Cancer. 2012 Sep;12(9):637

Abstract

Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of cancer. Genetic and biochemical data have demonstrated that the growth and motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, have a causal role in all of these processes, thus providing a strong rationale for targeting these molecules in cancer. Parallel progress in understanding the structure and function of HGF/SF, MET and associated signalling components has led to the successful development of blocking antibodies and a large number of small-molecule MET kinase inhibitors. In this Review, we discuss these advances, as well as results from recent clinical studies that demonstrate that inhibiting MET signalling in several types of solid human tumours has major therapeutic value.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7443-8 - PubMed
    1. Cancer Res. 2009 Nov 1;69(21):8395-402 - PubMed
    1. Front Biosci. 2006 May 01;11:1302-10 - PubMed
    1. Biochem Biophys Res Commun. 1992 Nov 30;189(1):227-32 - PubMed
    1. Biol Cell. 2009 Sep;101(9):525-39 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources