Depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from Ecklonia cava edible brown seaweed
- PMID: 22232271
- DOI: 10.1271/bbb.110702
Depressive effects on the central nervous system and underlying mechanism of the enzymatic extract and its phlorotannin-rich fraction from Ecklonia cava edible brown seaweed
Abstract
Marine plants have been reported to possess various pharmacological properties; however, there have been few reports on their neuropharmacological effects. Terrestrial plants have depressive effects on the central nervous system (CNS) because of their polyphenols which make them effective as anticonvulsants and sleep inducers. We investigated in this study the depressive effects of the polyphenol-rich brown seaweed, Ecklonia cava (EC), on CNS. An EC enzymatic extract (ECEE) showed significant anticonvulsive (>500 mg/kg) and sleep-inducing (>500 mg/kg) effects on the respective mice seizure induced by picrotoxin and on the mice sleep induced by pentobarbital. The phlorotannin-rich fraction (PTRF) from ECEE significantly potentiated the pentobarbital-induced sleep at >50 mg/kg. PTRF had binding activity to the gamma aminobutyric acid type A (GABA(A))-benzodiazepine (BZD) receptors. The sleep-inducing effects of diazepam (DZP, a well-known GABA(A)-BZD agonist), ECEE, and PTRF were completely blocked by flumazenil, a well-known antagonist of GABA(A)-BZD receptors. These results imply that ECEE produced depressive effects on CNS by positive allosteric modulation of its phlorotannins on GABA(A)-BZD receptors like DZP. Our study proposes EC as a candidate for the effective treatment of neuropsychiatric disorders such as anxiety and insomnia.
Similar articles
-
Marine Polyphenol Phlorotannins as a Natural Sleep Aid for Treatment of Insomnia: A Review of Sedative-Hypnotic Effects and Mechanism of Action.Mar Drugs. 2022 Dec 10;20(12):774. doi: 10.3390/md20120774. Mar Drugs. 2022. PMID: 36547921 Free PMC article. Review.
-
Phlorotannins of the edible brown seaweed Ecklonia cava Kjellman induce sleep via positive allosteric modulation of gamma-aminobutyric acid type A-benzodiazepine receptor: A novel neurological activity of seaweed polyphenols.Food Chem. 2012 Jun 1;132(3):1133-1142. doi: 10.1016/j.foodchem.2011.08.040. Epub 2011 Aug 23. Food Chem. 2012. PMID: 29243592
-
Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol.Bioorg Med Chem. 2012 Jun 1;20(11):3493-501. doi: 10.1016/j.bmc.2012.04.011. Epub 2012 Apr 11. Bioorg Med Chem. 2012. PMID: 22543233
-
Effects of Hypericum montbretti extract on the central nervous system and involvement of GABA (A)/Benzodiazepine receptors in its pharmacological activity.Phytother Res. 2012 Nov;26(11):1695-700. doi: 10.1002/ptr.4629. Epub 2012 Mar 7. Phytother Res. 2012. PMID: 22395896
-
Phlorotannins from Ecklonia cava (Phaeophyceae): biological activities and potential health benefits.Biofactors. 2010 Nov-Dec;36(6):408-14. doi: 10.1002/biof.114. Epub 2010 Aug 27. Biofactors. 2010. PMID: 20803523 Review.
Cited by
-
Therapeutic effects of phlorotannins in the treatment of neurodegenerative disorders.Front Mol Neurosci. 2023 May 18;16:1193590. doi: 10.3389/fnmol.2023.1193590. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37305552 Free PMC article. Review.
-
Marine Polyphenol Phlorotannins as a Natural Sleep Aid for Treatment of Insomnia: A Review of Sedative-Hypnotic Effects and Mechanism of Action.Mar Drugs. 2022 Dec 10;20(12):774. doi: 10.3390/md20120774. Mar Drugs. 2022. PMID: 36547921 Free PMC article. Review.
-
Phenolics as GABAA Receptor Ligands: An Updated Review.Molecules. 2022 Mar 8;27(6):1770. doi: 10.3390/molecules27061770. Molecules. 2022. PMID: 35335130 Free PMC article. Review.
-
Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?Mar Drugs. 2021 Aug 26;19(9):484. doi: 10.3390/md19090484. Mar Drugs. 2021. PMID: 34564146 Free PMC article. Review.
-
The Seaweed Diet in Prevention and Treatment of the Neurodegenerative Diseases.Mar Drugs. 2021 Feb 26;19(3):128. doi: 10.3390/md19030128. Mar Drugs. 2021. PMID: 33652930 Free PMC article. Review.