Circulating microRNAs: biomarkers or mediators of cardiovascular diseases?
- PMID: 22011751
- DOI: 10.1161/ATVBAHA.111.226696
Circulating microRNAs: biomarkers or mediators of cardiovascular diseases?
Abstract
MicroRNAs (miRs) are small, noncoding RNAs that posttranscriptionally control gene expression by inhibiting protein translation or inducing target mRNA destabilization. Besides their intracellular function, recent studies demonstrate that miRs can be exported or released by cells and circulate with the blood in a remarkably stable form. The discovery of circulating miRs opens up intriguing possibilities to use the circulating miR patterns as biomarker for cardiovascular diseases. Cardiac injury as it occurs after acute myocardial infarction increases the circulating levels of several myocardial-derived miRs (eg, miR-1, miR-133, miR-499, miR-208), whereas patients with coronary artery disease or diabetes showed reduced levels of endothelial-enriched miRs, such as miR-126. This review article summarizes the current clinical and experimental studies addressing the role of circulating miRs as a diagnostic or prognostic biomarker in cardiovascular disease. In addition, the mechanisms by which miRs are released and their putative function as long-distance communicators are discussed.
Similar articles
-
Transcoronary concentration gradients of circulating microRNAs.Circulation. 2011 Nov 1;124(18):1936-44. doi: 10.1161/CIRCULATIONAHA.111.037572. Epub 2011 Oct 3. Circulation. 2011. PMID: 21969012
-
A subset of circulating microRNAs are predictive for cardiac death after discharge for acute myocardial infarction.Biochem Biophys Res Commun. 2012 Oct 19;427(2):280-4. doi: 10.1016/j.bbrc.2012.09.039. Epub 2012 Sep 17. Biochem Biophys Res Commun. 2012. PMID: 22995291
-
Circulating miRNAs: reflecting or affecting cardiovascular disease?Curr Hypertens Rep. 2012 Dec;14(6):498-509. doi: 10.1007/s11906-012-0310-7. Curr Hypertens Rep. 2012. PMID: 22996205 Review.
-
Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction.Biochem Biophys Res Commun. 2010 Jan 1;391(1):73-7. doi: 10.1016/j.bbrc.2009.11.005. Epub 2009 Nov 5. Biochem Biophys Res Commun. 2010. PMID: 19896465
-
MicroRNAs in health and disease--basic science and clinical applications.Clin Lab. 2012;58(5-6):393-402. Clin Lab. 2012. PMID: 22783567 Review.
Cited by
-
MiRNA expression profiling reveals a potential role of microRNA-148b-3p in cerebral vasospasm in subarachnoid hemorrhage.Sci Rep. 2024 Sep 29;14(1):22539. doi: 10.1038/s41598-024-73579-2. Sci Rep. 2024. PMID: 39341923
-
Identification of circulating microRNA-126-3p as a new biomarker for coronary artery calcification.SAGE Open Med. 2024 Aug 18;12:20503121241272646. doi: 10.1177/20503121241272646. eCollection 2024. SAGE Open Med. 2024. PMID: 39161400 Free PMC article.
-
Decreased plasma miR-140-3p is associated with coronary artery disease.Heliyon. 2024 Feb 25;10(5):e26960. doi: 10.1016/j.heliyon.2024.e26960. eCollection 2024 Mar 15. Heliyon. 2024. PMID: 38444486 Free PMC article.
-
miR-548ag promotes DPP4 expression in hepatocytes through activation of TLR(7/8)/NF-κB pathway.Int J Obes (Lond). 2024 Jul;48(7):941-953. doi: 10.1038/s41366-024-01504-8. Epub 2024 Feb 29. Int J Obes (Lond). 2024. PMID: 38424257 Free PMC article.
-
Development of a risk assessment model for cardiac injury in patients newly diagnosed with acute myeloid leukemia based on a multicenter, real-world analysis in China.BMC Cancer. 2024 Jan 25;24(1):132. doi: 10.1186/s12885-024-11847-0. BMC Cancer. 2024. PMID: 38273254 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
