Role of natural product diversity in chemical biology

doi:10.1016/j.cbpa.2011.03.004

Review

. 2011 Jun;15(3):350-4.

doi: 10.1016/j.cbpa.2011.03.004. Epub 2011 Apr 12.

Role of natural product diversity in chemical biology

Jiyong Hong¹

Affiliations

PMID: 21489856
PMCID: PMC3110584
DOI: 10.1016/j.cbpa.2011.03.004

Review

Role of natural product diversity in chemical biology

Jiyong Hong. Curr Opin Chem Biol. 2011 Jun.

. 2011 Jun;15(3):350-4.

doi: 10.1016/j.cbpa.2011.03.004. Epub 2011 Apr 12.

Author

Jiyong Hong¹

Affiliation

¹ Department of Chemistry, Duke University, Durham, NC 27708, USA. jiyong.hong@duke.edu

PMID: 21489856
PMCID: PMC3110584
DOI: 10.1016/j.cbpa.2011.03.004

Abstract

Through the natural selection process, natural products possess a unique and vast chemical diversity and have been evolved for optimal interactions with biological macromolecules. Owing to their diversity, target affinity, and specificity, natural products have demonstrated enormous potential as modulators of biomolecular function, been an essential source for drug discovery, and provided design principles for combinatorial library development.

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Figures

**Figure 2**
Examples of natural products used in chemical biology and drug discovery

**Figure 3**
Comparison of target-oriented synthesis (TOS) and diversity-oriented synthesis (DOS)

See this image and copyright information in PMC

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References

1. Schreiber SL. The small-molecule approach to biology. Chem Eng News. 2003;81:51–61.
1. Stockwell BR. Exploring biology with small organic molecules. Nature. 2004;432:846–854. - PMC - PubMed
1. Wurdak H, Zhu S, Min KH, Aimone L, Lairson LL, Watson J, Chopiuk G, Demas J, Charette B, Weerapana E, Cravatt BF, Cline HT, Peters EC, Zhang J, Walker JR, Wu C, Chang J, Tuntland T, Cho CY, Schultz PG. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci USA. 2010;107:16542–16547. - PMC - PubMed
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1. Clardy J, Walsh C. Lessons from natural molecules. Nature. 2004;432:829–837. A discussion of the rich structural diversity and complexity of natural products. - PubMed

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[1] Schreiber SL. The small-molecule approach to biology. Chem Eng News. 2003;81:51–61.

[2] Schreiber SL. The small-molecule approach to biology. Chem Eng News. 2003;81:51–61.

[3] Stockwell BR. Exploring biology with small organic molecules. Nature. 2004;432:846–854. - PMC - PubMed

[4] Stockwell BR. Exploring biology with small organic molecules. Nature. 2004;432:846–854. - PMC - PubMed

[5] Wurdak H, Zhu S, Min KH, Aimone L, Lairson LL, Watson J, Chopiuk G, Demas J, Charette B, Weerapana E, Cravatt BF, Cline HT, Peters EC, Zhang J, Walker JR, Wu C, Chang J, Tuntland T, Cho CY, Schultz PG. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci USA. 2010;107:16542–16547. - PMC - PubMed

[6] Wurdak H, Zhu S, Min KH, Aimone L, Lairson LL, Watson J, Chopiuk G, Demas J, Charette B, Weerapana E, Cravatt BF, Cline HT, Peters EC, Zhang J, Walker JR, Wu C, Chang J, Tuntland T, Cho CY, Schultz PG. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci USA. 2010;107:16542–16547. - PMC - PubMed

[7] Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL. Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc Natl Acad Sci USA. 2010;107:12617–12622. - PMC - PubMed

[8] Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL. Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc Natl Acad Sci USA. 2010;107:12617–12622. - PMC - PubMed

[9] Clardy J, Walsh C. Lessons from natural molecules. Nature. 2004;432:829–837. A discussion of the rich structural diversity and complexity of natural products. - PubMed

[10] Clardy J, Walsh C. Lessons from natural molecules. Nature. 2004;432:829–837. A discussion of the rich structural diversity and complexity of natural products. - PubMed

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Role of natural product diversity in chemical biology

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Role of natural product diversity in chemical biology

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