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Review
. 2011 May;16(5):265-72.
doi: 10.1016/j.tplants.2011.02.010. Epub 2011 Mar 24.

Viral suppressors of RNA silencing

József Burgyán  1 , Zoltán Havelda
Affiliations
Review

Viral suppressors of RNA silencing

József Burgyán et al. Trends Plant Sci. 2011 May.

Abstract

The infection and replication of viruses in the host induce diverse mechanisms for combating viral infection. One of the best-studied antiviral defence mechanisms is based on RNA silencing. Consistently, several viral suppressors of RNA silencing (VSRs) have been identified from almost all plant virus genera, which are surprisingly diverse within and across kingdoms, exhibiting no obvious sequence similarities. VSRs efficiently inhibit host antiviral responses by interacting with the key components of cellular silencing machinery, often mimicking their normal cellular functions. Recent findings have revealed that the impact of VSRs on endogenous pathways is more complex and profound than had been estimated thus far. This review highlights the current understanding of and new insights into the mechanisms and functions of plant VSRs.

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