Probiotic manipulation of the gastrointestinal microbiota

doi:10.4161/gmic.1.5.13169

. 2010 Sep;1(5):335-338.

doi: 10.4161/gmic.1.5.13169. Epub 2010 Jul 27.

Probiotic manipulation of the gastrointestinal microbiota

Marcus Rauch¹, Susan V Lynch

Affiliations

PMID: 21327043
PMCID: PMC3023619
DOI: 10.4161/gmic.1.5.13169

Probiotic manipulation of the gastrointestinal microbiota

Marcus Rauch et al. Gut Microbes. 2010 Sep.

. 2010 Sep;1(5):335-338.

doi: 10.4161/gmic.1.5.13169. Epub 2010 Jul 27.

Authors

Marcus Rauch¹, Susan V Lynch

Affiliation

¹ Colitis and Crohn's Disease Center; Division of Gastroenterology; Department of Medicine; University of California at San Francisco; San Francisco, CA USA.

PMID: 21327043
PMCID: PMC3023619
DOI: 10.4161/gmic.1.5.13169

Abstract

In a recent publication we examined whether high abundance of a probiotic species, Lactobacillus casei subsp. rhamnosus GG (LGG), impacted the overall composition of the gastrointestinal (GI) microbiota of six-month-old infants at high risk for asthma development. Profound GI microbiota restructuring and the establishment of significantly more even and putatively, functionally redundant consortia were characteristic of high LGG abundance. Here we discuss, in the context of more recently published data, support for the hypothesis that the beneficial effect of probiotic supplementation on human health lies in the formation of a stable and resilient gut ecosystem enriched for species that exert a concerted beneficial effect on the host immune system via direct and indirect mechanisms.

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References

1. Cheplin HA, Rettger LF. Studies on the Transformation of the intestinal flora, with special reference to the implantation of Bacillus Acidophilus: II. Feeding experiments on man. Proc Natl Acad Sci USA. 1920;6:1–3. - PMC - PubMed
1. Dethlefsen L, McFall-Ngai M, Relman DA. An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature. 2007;449:811–818. - PMC - PubMed
1. Fujimura KE, Slusher NA, Cabana MD, Lynch SV. Role of the gut microbiota in defining human health. Expert Rev Anti Infect Ther. 2010;8:435–454. - PMC - PubMed
1. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004;118:229–241. - PubMed
1. Hall JA, Bouladoux N, Sun CM, Wohlfert EA, Blank RB, Zhu Q, et al. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity. 2008;29:637–649. - PMC - PubMed

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[1] Cheplin HA, Rettger LF. Studies on the Transformation of the intestinal flora, with special reference to the implantation of Bacillus Acidophilus: II. Feeding experiments on man. Proc Natl Acad Sci USA. 1920;6:1–3. - PMC - PubMed

[2] Cheplin HA, Rettger LF. Studies on the Transformation of the intestinal flora, with special reference to the implantation of Bacillus Acidophilus: II. Feeding experiments on man. Proc Natl Acad Sci USA. 1920;6:1–3. - PMC - PubMed

[3] Dethlefsen L, McFall-Ngai M, Relman DA. An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature. 2007;449:811–818. - PMC - PubMed

[4] Dethlefsen L, McFall-Ngai M, Relman DA. An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature. 2007;449:811–818. - PMC - PubMed

[5] Fujimura KE, Slusher NA, Cabana MD, Lynch SV. Role of the gut microbiota in defining human health. Expert Rev Anti Infect Ther. 2010;8:435–454. - PMC - PubMed

[6] Fujimura KE, Slusher NA, Cabana MD, Lynch SV. Role of the gut microbiota in defining human health. Expert Rev Anti Infect Ther. 2010;8:435–454. - PMC - PubMed

[7] Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004;118:229–241. - PubMed

[8] Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004;118:229–241. - PubMed

[9] Hall JA, Bouladoux N, Sun CM, Wohlfert EA, Blank RB, Zhu Q, et al. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity. 2008;29:637–649. - PMC - PubMed

[10] Hall JA, Bouladoux N, Sun CM, Wohlfert EA, Blank RB, Zhu Q, et al. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity. 2008;29:637–649. - PMC - PubMed

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Probiotic manipulation of the gastrointestinal microbiota

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Probiotic manipulation of the gastrointestinal microbiota

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