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. 1991 Jul 12;66(1):107-19.
doi: 10.1016/0092-8674(91)90143-m.

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

K Vleminckx  1 , L Vakaet Jr, M Mareel, W Fiers, F van Roy
Affiliations

Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role

K Vleminckx et al. Cell. .

Abstract

A cDNA encoding the cell-cell adhesion molecule E-cadherin was transfected into highly invasive epithelial tumor cell lines of dog kidney or mouse mammary gland origin. Transfectants with a homogeneously high expression of E-cadherin showed a reproducible loss of activity in two types of in vitro invasion assays. Invasiveness of these transfectants could be reinduced specifically by treatment with anti-E-cadherin antibodies. In vivo, they formed partly differentiated tumors, instead of fully undifferentiated tumors. Alternatively, a plasmid encoding E-cadherin-specific anti-sense RNA was introduced into noninvasive ras-transformed cells with high endogenous E-cadherin expression. The resulting down-regulation, albeit partial, rendered the cells invasive. These data provide direct evidence that E-cadherin acts as an invasion suppressor molecule.

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