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Review
. 2010 May 19;11(5):2188-99.
doi: 10.3390/ijms11052188.

Apoptotic effects of chrysin in human cancer cell lines

Boon Yin Khoo  1 , Siang Ling Chua, Prabha Balaram
Affiliations
Review

Apoptotic effects of chrysin in human cancer cell lines

Boon Yin Khoo et al. Int J Mol Sci. .

Abstract

Chrysin is a natural flavonoid currently under investigation due to its important biological anti-cancer properties. In most of the cancer cells tested, chrysin has shown to inhibit proliferation and induce apoptosis, and is more potent than other tested flavonoids in leukemia cells, where chrysin is likely to act via activation of caspases and inactivation of Akt signaling in the cells. Moreover, structure-activity relationships have revealed that the chemical structure of chrysin meets the key structural requirements of flavonoids for potent cytotoxicity in leukemia cells. It is possible that combination therapy or modified chrysin could be more potent than single-agent use or administration of unmodified chrysin. This study may help to develop ways of improving the effectiveness of chrysin in the treatment of leukemia and other human cancers in vitro.

Keywords: apoptotic effect; chrysin; human cancers; in vitro.

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Figures

Figure 1.
Figure 1.
(A) Common chemical structure of flavones. Flavones have a common chemical structure consisting of fused A and C rings, and a phenyl B ring attached to position 2 of the C ring. (B) Chrysin is in the flavone subgroup of flavonoids and shares a common flavone structure with hydroxyls at position 5 and 7 of the A ring. Replacing the hydroxyl with a phosphate group at position 7, such as in diethyl chrysin-7-yl phosphate (CPE). (C) or at positions 5 and 7, such as in tetraethyl bis-phosphoric ester of chrysin (CP). (D), enhances the anti-cancer potential of the chrysin.
Figure 2.
Figure 2.
The PI3K/Akt signaling pathway. Chrysin is likely to act via activation of caspases and inactivation of Akt signaling in leukemia cells. (•) depicts chrysin.
See this image and copyright information in PMC

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References

    1. Robards K, Antolovich M. Analytical chemistry of fruit bioflavonoids: A review. Analyst. 1997;122:11–34.
    1. Pietta PG. Flavonoids as anti-oxidants. J. Nat. Prod. 2000;63:1035–1042. - PubMed
    1. Nijveldt RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA. Flavonoids: A review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr. 2001;74:418–425. - PubMed
    1. Kale A, Gawande S, Kotwal S. Cancer phytotherapeutics: role for flavonoids at the cellular level. Phytother. Res. 2008;22:567–577. - PubMed
    1. Awad R, Arnason JT, Trudeau V, Bergeron C, Budzinski JW, Foster BC, Merali Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): A medicinal plant with anxiolytic properties. Phytomedicine. 2003;10:640–649. - PubMed

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