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. 2010 Jan-Feb;56(1):92-8.
doi: 10.1590/s0104-42302010000100022.

Th1 and Th2 ummune responses related to pelvic endometriosis

Sergio Podgaec  1 , João Antonio Dias Junior, Charles Chapron, Ricardo Manoel de Oliveira, Edmund Chada Baracat, Maurício Simões Abrão
Affiliations
Free article

Th1 and Th2 ummune responses related to pelvic endometriosis

Sergio Podgaec et al. Rev Assoc Med Bras (1992). 2010 Jan-Feb.
Free article

Abstract

Objective: This study analyzed the relationship between clinical characteristics of endometriosis and Th1/Th2 immune response patterns.

Methods: A prospective study was performed with 65 patients with endometriosis (Group A) and 33 without the disease (Group B). Measurement of IL 2, 4 and 10, TNF-alpha and IFN-gamma was carried out in peripheral blood and peritoneal fluid.

Results: Serum TNF-alpha was higher in patients with endometriosis who had deep dyspareunia compared to controls (mean 4.5 pg/ml and 2.3 pg/ml, p<0.05). Among these patients (n=32), 65.5% had deep endometriosis. Patients with endometriosis and infertility had higher IL-2 concentrations in peritoneal fluid than controls (mean 5.9 pg/ml and 0.2 pg/ml, p<0.05). Among these patients (n=22), 63.5% (n=14) had deep endometriosis. A higher concentration of IL-10 was also observed in patients with ovarian endometriosis when compared to those without this type of disease, as well as when compared to control group patients (mean 50 pg/ml, 18.7 pg/ml and 25.7 pg/ml, p<0.05).

Conclusions: These results suggest that when specific clinical data are associated with a higher production of certain cytokines, there is a Th1 response pattern that may be related to deep infiltrating endometriosis.

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