IgE, mast cells, basophils, and eosinophils

doi:10.1016/j.jaci.2009.11.017

Review

. 2010 Feb;125(2 Suppl 2):S73-80.

doi: 10.1016/j.jaci.2009.11.017.

IgE, mast cells, basophils, and eosinophils

Kelly D Stone¹, Calman Prussin, Dean D Metcalfe

Affiliations

PMID: 20176269
PMCID: PMC2847274
DOI: 10.1016/j.jaci.2009.11.017

Review

IgE, mast cells, basophils, and eosinophils

Kelly D Stone et al. J Allergy Clin Immunol. 2010 Feb.

. 2010 Feb;125(2 Suppl 2):S73-80.

doi: 10.1016/j.jaci.2009.11.017.

Authors

Kelly D Stone¹, Calman Prussin, Dean D Metcalfe

Affiliation

¹ Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1881, USA.

PMID: 20176269
PMCID: PMC2847274
DOI: 10.1016/j.jaci.2009.11.017

Abstract

IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcepsilonRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis.

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References

1. Smith P, Ownby, DR. Clinical Significance of IgE. In: Adkinson N, Bochner BS, Busse WW, Holgate ST, Lemanske RF, Simons FER, editors. Middleton's Allergy: Principles and Practice. 7th ed Mosby Elsevier; 2009.
1. Vercelli D. Immunobiology of IgE. In: Adkinson N, Bochner BS, Busse WW, Holgate ST, Lemanske RF, Simons FER, editors. Middleton's Allergy: Principles and Practice. 7th ed Mosby Elsevier; 2009.
1. Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol. 2008;8:205–17. - PubMed
1. MacGlashan D., Jr. IgE receptor and signal transduction in mast cells and basophils. Curr Opin Immunol. 2008;20:717–23. - PubMed
1. Gomez G, Jogie-Brahim S, Shima M, Schwartz LB. Omalizumab reverses the phenotypic and functional effects of IgE-enhanced Fc epsilonRI on human skin mast cells. J Immunol. 2007;179:1353–61. - PMC - PubMed

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[1] Smith P, Ownby, DR. Clinical Significance of IgE. In: Adkinson N, Bochner BS, Busse WW, Holgate ST, Lemanske RF, Simons FER, editors. Middleton's Allergy: Principles and Practice. 7th ed Mosby Elsevier; 2009.

[2] Smith P, Ownby, DR. Clinical Significance of IgE. In: Adkinson N, Bochner BS, Busse WW, Holgate ST, Lemanske RF, Simons FER, editors. Middleton's Allergy: Principles and Practice. 7th ed Mosby Elsevier; 2009.

[3] Vercelli D. Immunobiology of IgE. In: Adkinson N, Bochner BS, Busse WW, Holgate ST, Lemanske RF, Simons FER, editors. Middleton's Allergy: Principles and Practice. 7th ed Mosby Elsevier; 2009.

[4] Vercelli D. Immunobiology of IgE. In: Adkinson N, Bochner BS, Busse WW, Holgate ST, Lemanske RF, Simons FER, editors. Middleton's Allergy: Principles and Practice. 7th ed Mosby Elsevier; 2009.

[5] Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol. 2008;8:205–17. - PubMed

[6] Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol. 2008;8:205–17. - PubMed

[7] MacGlashan D., Jr. IgE receptor and signal transduction in mast cells and basophils. Curr Opin Immunol. 2008;20:717–23. - PubMed

[8] MacGlashan D., Jr. IgE receptor and signal transduction in mast cells and basophils. Curr Opin Immunol. 2008;20:717–23. - PubMed

[9] Gomez G, Jogie-Brahim S, Shima M, Schwartz LB. Omalizumab reverses the phenotypic and functional effects of IgE-enhanced Fc epsilonRI on human skin mast cells. J Immunol. 2007;179:1353–61. - PMC - PubMed

[10] Gomez G, Jogie-Brahim S, Shima M, Schwartz LB. Omalizumab reverses the phenotypic and functional effects of IgE-enhanced Fc epsilonRI on human skin mast cells. J Immunol. 2007;179:1353–61. - PMC - PubMed

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IgE, mast cells, basophils, and eosinophils

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IgE, mast cells, basophils, and eosinophils

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