Review
doi: 10.1038/onc.2009.519.
Epub 2010 Jan 25.
Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1
Affiliations
- PMID: 20101204
- DOI: 10.1038/onc.2009.519
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Review
Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1
Oncogene.
.
Erratum in
- Oncogene. 2010 Dec 9;29(49):6508
Abstract
Beclin 1 has a key role in the initiation of autophagy, a process of self-cannibalism in which cytoplasmic constituents are sequestered and targeted for lysosomal degradation. In a recent issue of Cell Death & Disease, Wirawan et al. report the significant finding that caspases can cleave Beclin 1, thereby destroying its pro-autophagic activity. Moreover, the C-terminal fragment of Beclin 1 that results from this cleavage acquires a new function and can amplify mitochondrion-mediated apoptosis. Of note, the BH3 domain of Beclin 1 remains within the N-terminal fragment, which has no detectable pro-apoptotic activity. These findings provide important insights into the molecular cross talk between autophagy and apoptosis.
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