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. 2009 Dec 15;49(12):1946-9.
doi: 10.1086/648447.

Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid

Maryjo Lechowicz  1 , Dirk P Dittmer, Jeannette Y Lee, Susan E Krown, William Wachsman, David Aboulafia, Bruce J Dezube, Lee Ratner, Jonathan Said, Richard F Ambinder
Affiliations

Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid

Maryjo Lechowicz et al. Clin Infect Dis. .

Abstract

The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.

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Conflict of interest statement

All authors: no conflicts

Figures

Figure 1
Figure 1
KSHV mRNA and DNA. A. Correlation of KSHV mRNA levels with VA trough levels after treatment. The VA trough level is shown on the horizontal and relative mRNA levels (dCT) on the vertical axes. The human housekeeping mRNA hprt, KSHV latent mRNA LANA, KSHV orf22, which exhibited a linear trend (p≤0.05) and orf22 as measured by a second independent primer are shown. Also shown are the linear regression lines and residuals. B. KSHV DNA copy number in blood. Vertical bars corresponding to each patient are grouped as pre-treatment, day 8, and day 29. The Y axis shows the log10 of KSHV copy number.
Figure 1
Figure 1
KSHV mRNA and DNA. A. Correlation of KSHV mRNA levels with VA trough levels after treatment. The VA trough level is shown on the horizontal and relative mRNA levels (dCT) on the vertical axes. The human housekeeping mRNA hprt, KSHV latent mRNA LANA, KSHV orf22, which exhibited a linear trend (p≤0.05) and orf22 as measured by a second independent primer are shown. Also shown are the linear regression lines and residuals. B. KSHV DNA copy number in blood. Vertical bars corresponding to each patient are grouped as pre-treatment, day 8, and day 29. The Y axis shows the log10 of KSHV copy number.
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