The gut microbiota shapes intestinal immune responses during health and disease
- PMID: 19343057
- PMCID: PMC4095778
- DOI: 10.1038/nri2515
The gut microbiota shapes intestinal immune responses during health and disease
Erratum in
- Nat Rev Immunol. 2009 Aug;9(8):600
Abstract
Immunological dysregulation is the cause of many non-infectious human diseases such as autoimmunity, allergy and cancer. The gastrointestinal tract is the primary site of interaction between the host immune system and microorganisms, both symbiotic and pathogenic. In this Review we discuss findings indicating that developmental aspects of the adaptive immune system are influenced by bacterial colonization of the gut. We also highlight the molecular pathways that mediate host-symbiont interactions that regulate proper immune function. Finally, we present recent evidence to support that disturbances in the bacterial microbiota result in dysregulation of adaptive immune cells, and this may underlie disorders such as inflammatory bowel disease. This raises the possibility that the mammalian immune system, which seems to be designed to control microorganisms, is in fact controlled by microorganisms.
Figures
Similar articles
-
Host-microbiota interactions in inflammatory bowel disease.Nat Rev Immunol. 2020 Jul;20(7):411-426. doi: 10.1038/s41577-019-0268-7. Epub 2020 Jan 31. Nat Rev Immunol. 2020. PMID: 32005980 Review.
-
Regulation of intestinal homeostasis and immunity with probiotic lactobacilli.Trends Immunol. 2013 May;34(5):208-15. doi: 10.1016/j.it.2013.01.005. Epub 2013 Feb 26. Trends Immunol. 2013. PMID: 23485516 Review.
-
[Intestinal immune response is regulated by gut microbe].Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(6):408-415. doi: 10.2177/jsci.40.408. Nihon Rinsho Meneki Gakkai Kaishi. 2017. PMID: 29367525 Review. Japanese.
-
The intestinal microbiota in inflammatory bowel diseases: time to connect with the host.Curr Opin Gastroenterol. 2010 Jul;26(4):327-31. doi: 10.1097/MOG.0b013e328339536b. Curr Opin Gastroenterol. 2010. PMID: 20445446 Review.
-
An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer.J Exp Med. 2010 Aug 2;207(8):1573-7. doi: 10.1084/jem.20101330. J Exp Med. 2010. PMID: 20679404 Free PMC article. Review.
Cited by
-
Effects of Lagenaria siceraria (Molina) Standl polysaccharides on growth performance, immune function, cecum microorganisms and short-chain fatty acids in broilers.Front Vet Sci. 2024 Oct 15;11:1428623. doi: 10.3389/fvets.2024.1428623. eCollection 2024. Front Vet Sci. 2024. PMID: 39474276 Free PMC article.
-
Oral Microbial Translocation Genes in Gastrointestinal Cancers: Insights from Metagenomic Analysis.Microorganisms. 2024 Oct 18;12(10):2086. doi: 10.3390/microorganisms12102086. Microorganisms. 2024. PMID: 39458395 Free PMC article.
-
A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues.Nat Commun. 2024 Oct 10;15(1):8794. doi: 10.1038/s41467-024-53149-w. Nat Commun. 2024. PMID: 39389974 Free PMC article.
-
Caspase-8 in inflammatory diseases: a potential therapeutic target.Cell Mol Biol Lett. 2024 Oct 8;29(1):130. doi: 10.1186/s11658-024-00646-x. Cell Mol Biol Lett. 2024. PMID: 39379817 Free PMC article. Review.
-
The human volatilome meets cancer diagnostics: past, present, and future of noninvasive applications.Metabolomics. 2024 Oct 7;20(5):113. doi: 10.1007/s11306-024-02180-5. Metabolomics. 2024. PMID: 39375265 Review.
References
-
- Ley RE, Peterson DA, Gordon JI. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell. 2006;124:837–48. - PubMed
-
- Hooper LV. Bacterial contributions to mammalian gut development. Trends Microbiol. 2004;12:129–34. - PubMed
-
- Mazmanian SK, Kasper DL. The love-hate relationship between bacterial polysaccharides and the host immune system. Nat Rev Immunol. 2006;6:849–58. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources