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. 2009 Mar;37(4):1297-307.
doi: 10.1093/nar/gkn1008. Epub 2009 Jan 12.

Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases

Gil-Mi Ryu  1 , Pamela Song, Kyu-Won Kim, Kyung-Soo Oh, Keun-Joon Park, Jong Hun Kim
Affiliations

Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases

Gil-Mi Ryu et al. Nucleic Acids Res. 2009 Mar.

Abstract

We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions. Therefore, a comparison of phosphovariants between individuals or between species can give clues about phenotypic differences. We categorized phosphovariants into three subtypes and developed a system that predicts them. Our method can be used to screen important polymorphisms and help to identify the mechanisms of genetic diseases.

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Figures

Figure 1.
Figure 1.
Schematic illustration of phosphovariants according to their types.
Figure 2.
Figure 2.
Sequence logos of amino acid sequences near phosphorylation sites recognized by the CMGC kinase group. The horizontal axis represents sequential positions relative to the phosphorylation site. The vertical axis represents decreases in uncertainty. Each letter refers to an amino acid. As the frequency of an amino acid at a given position increases, its height increases.
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References

    1. Hunter T. Signaling–2000 and beyond. Cell. 2000;100:113–127. - PubMed
    1. Dash PK, Moore AN, Kobori N, Runyan JD. Molecular activity underlying working memory. Learn. Mem. 2007;14:554–563. - PubMed
    1. Hunter T, Karin M. The regulation of transcription by phosphorylation. Cell. 1992;70:375–387. - PubMed
    1. Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat. Biotechnol. 2006;24:1285–1292. - PubMed
    1. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006;127:635–648. - PubMed

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