Mitochondrial dysfunction in type 2 diabetes and obesity
- PMID: 18775360
- DOI: 10.1016/j.ecl.2008.06.006
Mitochondrial dysfunction in type 2 diabetes and obesity
Abstract
Insulin resistance in skeletal muscle is a major hallmark of type 2 diabetes mellitus (T2D) and obesity that is characterized by impaired insulin-mediated glucose transport and glycogen synthesis and by increased intramyocellular content of lipid metabolites. Several studies have provided evidence for mitochondrial dysfunction in skeletal muscle of type 2 diabetic and prediabetic subjects, primarily due to a lower content of mitochondria (mitochondrial biogenesis) and possibly to a reduced functional capacity per mitochondrion. This article discusses the latest advances in the understanding of the molecular mechanisms underlying insulin resistance in human skeletal muscle in T2D and obesity, with a focus on possible links between insulin resistance and mitochondrial dysfunction.
Similar articles
-
Type 2 diabetes mellitus and skeletal muscle metabolic function.Physiol Behav. 2008 May 23;94(2):252-8. doi: 10.1016/j.physbeh.2008.01.020. Epub 2008 Jan 31. Physiol Behav. 2008. PMID: 18342897 Review.
-
Lipid metabolism, exercise and insulin action.Essays Biochem. 2006;42:47-59. doi: 10.1042/bse0420047. Essays Biochem. 2006. PMID: 17144879 Review.
-
Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes.Int J Biochem Cell Biol. 2009 Oct;41(10):1846-54. doi: 10.1016/j.biocel.2009.02.004. Epub 2009 Feb 20. Int J Biochem Cell Biol. 2009. PMID: 19703653 Review.
-
Metabolic fluxes in skeletal muscle in relation to obesity and insulin resistance.Best Pract Res Clin Endocrinol Metab. 2005 Sep;19(3):391-403. doi: 10.1016/j.beem.2005.04.001. Best Pract Res Clin Endocrinol Metab. 2005. PMID: 16150382 Review.
-
Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: Hope from natural mitochondrial nutrients.Adv Drug Deliv Rev. 2009 Nov 30;61(14):1343-52. doi: 10.1016/j.addr.2009.06.007. Epub 2009 Aug 27. Adv Drug Deliv Rev. 2009. PMID: 19716392 Review.
Cited by
-
Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function.EMBO Rep. 2023 Apr 5;24(4):e54731. doi: 10.15252/embr.202254731. Epub 2023 Feb 27. EMBO Rep. 2023. PMID: 36847607 Free PMC article.
-
β2-adrenergic receptor-mediated mitochondrial biogenesis improves skeletal muscle recovery following spinal cord injury.Exp Neurol. 2019 Dec;322:113064. doi: 10.1016/j.expneurol.2019.113064. Epub 2019 Sep 13. Exp Neurol. 2019. PMID: 31525347 Free PMC article.
-
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle.PLoS One. 2015 Dec 15;10(12):e0145244. doi: 10.1371/journal.pone.0145244. eCollection 2015. PLoS One. 2015. PMID: 26671069 Free PMC article.
-
Activity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese mice.PLoS One. 2012;7(10):e47996. doi: 10.1371/journal.pone.0047996. Epub 2012 Oct 24. PLoS One. 2012. PMID: 23110155 Free PMC article.
-
Transcription Factor Movement and Exercise-Induced Mitochondrial Biogenesis in Human Skeletal Muscle: Current Knowledge and Future Perspectives.Int J Mol Sci. 2022 Jan 28;23(3):1517. doi: 10.3390/ijms23031517. Int J Mol Sci. 2022. PMID: 35163441 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
