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Review
. 2008 Aug;20(4):378-85.
doi: 10.1016/j.ceb.2008.05.009. Epub 2008 Jul 5.

Cell biology of lipid droplets

Christoph Thiele  1 , Johanna Spandl
Affiliations
Review

Cell biology of lipid droplets

Christoph Thiele et al. Curr Opin Cell Biol. 2008 Aug.

Abstract

Lipid storage has attracted much attention in the past years, both by the broader public and the biomedical scientific community. Driven by concerns about the obesity epidemic that affects most industrialized countries and even substantial parts of the population in less and least developed countries, work from researchers of many disciplines has shed light on the genetics, the physiology, and the cellular mechanisms of fat accumulation. This review focuses on the actual organelle of fat deposition, the lipid droplet (LD), and on the recent progress in mechanistic understanding of processes like LD biogenesis, LD growth and degradation, protein targeting to LDs and LD fusion.

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