Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Jul-Aug;1777(7-8):740-6.
doi: 10.1016/j.bbabio.2008.04.007. Epub 2008 Apr 11.

Is supercomplex organization of the respiratory chain required for optimal electron transfer activity?

M L Genova  1 , A Baracca, A Biondi, G Casalena, M Faccioli, A I Falasca, G Formiggini, G Sgarbi, G Solaini, G Lenaz
Affiliations
Free article
Review

Is supercomplex organization of the respiratory chain required for optimal electron transfer activity?

M L Genova et al. Biochim Biophys Acta. 2008 Jul-Aug.
Free article

Abstract

The supra-molecular assembly of the main respiratory chain enzymatic complexes in the form of "super-complexes" has been proved by structural and functional experimental evidence. This evidence strongly contrasts the previously accepted Random Diffusion Model stating that the complexes are functionally connected by lateral diffusion of small redox molecules (i.e. Coenzyme Q and cytochrome c). This review critically examines the available evidence and provides an analysis of the functional consequences of the intermolecular association of the respiratory complexes pointing out the role of Coenzyme Q and of cytochrome c as channeled or as freely diffusing intermediates in the electron transfer activity of their partner enzymes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources