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Clinical Trial
. 2007 Nov 30;21(18):2537-9.
doi: 10.1097/QAD.0b013e3282f12362.

Association between specific enfuvirtide resistance mutations and CD4 cell response during enfuvirtide-based therapy

Thomas E Melby  1 , Michael Despirito, Ralph A Demasi, Gabrielle Heilek, James A Thommes, Michael L Greenberg, Neil Graham
Affiliations
Clinical Trial

Association between specific enfuvirtide resistance mutations and CD4 cell response during enfuvirtide-based therapy

Thomas E Melby et al. AIDS. .

Abstract

Analysis of CD4 cell responses during 48 weeks of enfuvirtide therapy after virological failure (analysis of covariance) demonstrated significant associations between V38 mutations (n = 58 subjects) and continued CD4 cell increases and between Q40 mutations (n = 8) and loss of CD4 cell benefit (+34 versus -95 cells/mul, P < 0.001). Subjects with N43 (n = 20) or other mutations (n = 48) had intermediate CD4 cell responses. These data suggest that key enfuvirtide resistance mutations may be associated with reduced viral pathogenicity in vivo.

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