The lipid profile in psoriasis: a controlled study
- PMID: 17958837
- DOI: 10.1111/j.1468-3083.2007.02260.x
The lipid profile in psoriasis: a controlled study
Abstract
Background: Psoriasis is an inflammatory dermatosis that is characterized with hyperproliferation of keratinocytes and inflammatory infiltration in the epidermis and dermis. The high prevalence of atherosclerosis has been reported in psoriatic patients. High serum lipid level has been suggested in the pathogenesis of this phenomenon. In this study, our purpose was to compare the lipid profile in psoriatic patients with non-affected persons.
Methods: This study was designed and conducted as a case-control assay with 50 cases in the patient and control groups, respectively. The lipid profile, including serum level of triglyceride, cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were assessed in both groups.
Results: The patient and control groups each consisted of 50 cases (39 male and 11 female). The serum triglyceride, cholesterol, and LDL was significantly higher in psoriatic patients (P < 0.05) but not for HDL (P = 0.29).
Conclusion: This study, like previous assays, shows that high serum lipid level is significantly more common in psoriasis. This fact may be responsible for higher prevalence of cardiovascular accident in psoriatic patients. It may be useful to do early screening and treatment of hyperlipidaemia in psoriasis to prevent the atherosclerosis and its complications.
Similar articles
-
Serum lipid level in Iraqi patients with psoriasis.Skinmed. 2010 Jul-Aug;8(4):204-6. Skinmed. 2010. PMID: 21137604
-
Serum lipid level in Iranian patients with psoriasis.J Eur Acad Dermatol Venereol. 2007 Jul;21(6):802-5. doi: 10.1111/j.1468-3083.2006.02099.x. J Eur Acad Dermatol Venereol. 2007. PMID: 17567311
-
Activity of serum lipase [EC 3.1.1.3] and the diversity of serum lipid profile in psoriasis.Med Sci Monit. 2002 Jan;8(1):CR9-CR13. Med Sci Monit. 2002. PMID: 11782673
-
Cardiovascular aspects of psoriasis: an updated review.Int J Dermatol. 2013 Feb;52(2):153-62. doi: 10.1111/j.1365-4632.2012.05584.x. Int J Dermatol. 2013. PMID: 23347301 Review.
-
Lipid disturbances in psoriasis: an update.Mediators Inflamm. 2010;2010:535612. doi: 10.1155/2010/535612. Epub 2010 Jul 20. Mediators Inflamm. 2010. PMID: 20706605 Free PMC article. Review.
Cited by
-
Integrating protein interaction and pathway crosstalk network reveals a promising therapeutic approach for psoriasis through apoptosis induction.Sci Rep. 2024 Sep 27;14(1):22103. doi: 10.1038/s41598-024-73746-5. Sci Rep. 2024. PMID: 39333640 Free PMC article.
-
The influence of adalimumab treatment on the systemic gene expression in patients with psoriatic arthritis - preliminary report.Arch Med Sci. 2021 Mar 26;19(4):1080-1091. doi: 10.5114/aoms/113027. eCollection 2023. Arch Med Sci. 2021. PMID: 37560743 Free PMC article.
-
Circulating ANGPTL8 as a Potential Protector of Metabolic Complications in Patients with Psoriasis.J Clin Med. 2023 Mar 17;12(6):2346. doi: 10.3390/jcm12062346. J Clin Med. 2023. PMID: 36983346 Free PMC article.
-
Biologics for Reducing Cardiovascular Risk in Psoriasis Patients.J Clin Med. 2023 Feb 1;12(3):1162. doi: 10.3390/jcm12031162. J Clin Med. 2023. PMID: 36769825 Free PMC article. Review.
-
Alterations of HDL's to piHDL's Proteome in Patients with Chronic Inflammatory Diseases, and HDL-Targeted Therapies.Pharmaceuticals (Basel). 2022 Oct 18;15(10):1278. doi: 10.3390/ph15101278. Pharmaceuticals (Basel). 2022. PMID: 36297390 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
