Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007;35(22):7485-96.
doi: 10.1093/nar/gkm860. Epub 2007 Oct 16.

Caloric restriction and genomic stability

Ahmad R Heydari  1 , Archana Unnikrishnan, Lisa Ventrella Lucente, Arlan Richardson
Affiliations
Review

Caloric restriction and genomic stability

Ahmad R Heydari et al. Nucleic Acids Res. 2007.

Abstract

Caloric restriction (CR) reduces the incidence and progression of spontaneous and induced tumors in laboratory rodents while increasing mean and maximum life spans. It has been suggested that CR extends longevity and reduces age-related pathologies by reducing the levels of DNA damage and mutations that accumulate with age. This hypothesis is attractive because the integrity of the genome is essential to a cell/organism and because it is supported by observations that both cancer and immunological defects, which increase significantly with age and are delayed by CR, are associated with changes in DNA damage and/or DNA repair. Over the last three decades, numerous laboratories have examined the effects of CR on the integrity of the genome and the ability of cells to repair DNA. The majority of studies performed indicate that the age-related increase in oxidative damage to DNA is significantly reduced by CR. Early studies suggest that CR reduces DNA damage by enhancing DNA repair. With the advent of genomic technology and our increased understanding of specific repair pathways, CR has been shown to have a significant effect on major DNA repair pathways, such as NER, BER and double-strand break repair.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Modulation of genomic stability.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. McCay C.M., Crowell M.F., Maynard L.A. The effect of retarded growth upon the length of life span and upon the ultimate body size. J. Nutr. 1935;10:63–79. - PubMed
    1. Yu B.P., Masoro E.J., Murata I., Bertrand H.A., Lynd F.T. Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, growth, lean body mass and disease. J. Gerontol. 1982;37:130–141. - PubMed
    1. Weindruch R., Walford R.L., Fligiel S., Guthrie D. The retardation of aging in mice by dietary restriction: Longevity, cancer, immunity and lifetime energy intake. J. Nutr. 1986;116:654. - PubMed
    1. Masoro E.J. Food restriction in rodents: An evaluation of its role in the study of aging. J. Gerontol. 1988;43:B59–B64. - PubMed
    1. Masoro E.J., Shimokawa I., Yu B.P. Retardation of the aging processes in rats by food restriction. Ann. N. Y. Acad. Sci. 1991;621:337–352. - PubMed

Publication types