Innate immunity of the newborn: basic mechanisms and clinical correlates
- PMID: 17457344
- DOI: 10.1038/nri2075
Innate immunity of the newborn: basic mechanisms and clinical correlates
Abstract
The fetus and newborn face a complex set of immunological demands, including protection against infection, avoidance of harmful inflammatory immune responses that can lead to pre-term delivery, and balancing the transition from a sterile intra-uterine environment to a world that is rich in foreign antigens. These demands shape a distinct neonatal innate immune system that is biased against the production of pro-inflammatory cytokines. This bias renders newborns at risk of infection and impairs responses to many vaccines. This Review describes innate immunity in newborns and discusses how this knowledge might be used to prevent and treat infection in this vulnerable population.
Similar articles
-
Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists.J Endotoxin Res. 2005;11(2):113-6. doi: 10.1179/096805105X37376. J Endotoxin Res. 2005. PMID: 15949138 Review.
-
Phenotype and function of neonatal DC.Eur J Immunol. 2009 Jan;39(1):26-35. doi: 10.1002/eji.200838391. Eur J Immunol. 2009. PMID: 19137537 Review.
-
Neonatal innate immunity in allergy development.Curr Opin Pediatr. 2009 Dec;21(6):762-9. doi: 10.1097/MOP.0b013e3283325e3a. Curr Opin Pediatr. 2009. PMID: 19770766 Review.
-
Innate cellular immune responses in newborns.Clin Immunol. 2006 Feb-Mar;118(2-3):137-44. doi: 10.1016/j.clim.2005.10.012. Epub 2005 Dec 27. Clin Immunol. 2006. PMID: 16377252 Review.
-
The developing immune system - from foetus to toddler.Acta Paediatr. 2012 Feb;101(2):120-7. doi: 10.1111/j.1651-2227.2011.02494.x. Epub 2011 Nov 10. Acta Paediatr. 2012. PMID: 22003882 Review.
Cited by
-
Cross-protective immunity against o'nyong-nyong virus afforded by a novel recombinant chikungunya vaccine.Vaccine. 2012 Jun 29;30(31):4638-43. doi: 10.1016/j.vaccine.2012.04.099. Epub 2012 May 11. Vaccine. 2012. PMID: 22583812 Free PMC article.
-
Interleukin 4/13 signaling in cardiac regeneration and repair.Am J Physiol Heart Circ Physiol. 2022 Nov 1;323(5):H833-H844. doi: 10.1152/ajpheart.00310.2022. Epub 2022 Sep 23. Am J Physiol Heart Circ Physiol. 2022. PMID: 36149768 Free PMC article. Review.
-
Immunomodulation of tahneeq method in IL-12 and CD8+ T-Lymphocyte, an in-vivo study in neonatal rats.Saudi J Biol Sci. 2020 Oct;27(10):2645-2650. doi: 10.1016/j.sjbs.2020.05.046. Epub 2020 Jun 4. Saudi J Biol Sci. 2020. PMID: 32994723 Free PMC article.
-
Bacteriological profile and antibiotic resistance in newborn infants with possible community-acquired neonatal sepsis in Khartoum State, Sudan.Sudan J Paediatr. 2021;21(1):13-22. doi: 10.24911/SJP.106-1601909519. Sudan J Paediatr. 2021. PMID: 33879938 Free PMC article.
-
The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.PLoS One. 2013;8(3):e58164. doi: 10.1371/journal.pone.0058164. Epub 2013 Mar 4. PLoS One. 2013. PMID: 23483986 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical