Innate immunity of the newborn: basic mechanisms and clinical correlates

doi:10.1038/nri2075

Review

. 2007 May;7(5):379-90.

doi: 10.1038/nri2075.

Innate immunity of the newborn: basic mechanisms and clinical correlates

Ofer Levy¹

Affiliations

Affiliation

¹ Department of Medicine, Division of Infectious Diseases, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA. ofer.levy@childrens.harvard.edu

PMID: 17457344
DOI: 10.1038/nri2075

Review

Innate immunity of the newborn: basic mechanisms and clinical correlates

Ofer Levy. Nat Rev Immunol. 2007 May.

. 2007 May;7(5):379-90.

doi: 10.1038/nri2075.

Author

Ofer Levy¹

Affiliation

¹ Department of Medicine, Division of Infectious Diseases, Children's Hospital Boston and Harvard Medical School, Boston, MA 02115, USA. ofer.levy@childrens.harvard.edu

PMID: 17457344
DOI: 10.1038/nri2075

Abstract

The fetus and newborn face a complex set of immunological demands, including protection against infection, avoidance of harmful inflammatory immune responses that can lead to pre-term delivery, and balancing the transition from a sterile intra-uterine environment to a world that is rich in foreign antigens. These demands shape a distinct neonatal innate immune system that is biased against the production of pro-inflammatory cytokines. This bias renders newborns at risk of infection and impairs responses to many vaccines. This Review describes innate immunity in newborns and discusses how this knowledge might be used to prevent and treat infection in this vulnerable population.

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Innate immunity of the newborn: basic mechanisms and clinical correlates

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Innate immunity of the newborn: basic mechanisms and clinical correlates

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