The roles of intracellular protein-degradation pathways in neurodegeneration
- PMID: 17051204
- DOI: 10.1038/nature05291
The roles of intracellular protein-degradation pathways in neurodegeneration
Abstract
Many late-onset neurodegenerative diseases, including Parkinson's disease and Huntington's disease, are associated with the formation of intracellular aggregates by toxic proteins. It is therefore crucial to understand the factors that regulate the steady-state levels of these 'toxins', at both the synthetic and degradation stages. The degradation pathways acting on such aggregate-prone cytosolic proteins include the ubiquitin-proteasome system and macroautophagy. Dysfunction of the ubiquitin-proteasome or macroautophagy pathways might contribute to the pathology of various neurodegenerative conditions. However, enhancing macroautophagy with drugs such as rapamycin could offer a tractable therapeutic strategy for a number of these diseases.
Similar articles
-
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Exp Mol Med. 2015 Mar 13;47(3):e147. doi: 10.1038/emm.2014.117. Exp Mol Med. 2015. PMID: 25766616 Free PMC article. Review.
-
Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications.Curr Top Dev Biol. 2006;76:89-101. doi: 10.1016/S0070-2153(06)76003-3. Curr Top Dev Biol. 2006. PMID: 17118264 Review.
-
Ubiquitin proteasome system as a pharmacological target in neurodegeneration.Expert Rev Neurother. 2006 Sep;6(9):1337-47. doi: 10.1586/14737175.6.9.1337. Expert Rev Neurother. 2006. PMID: 17009921 Review.
-
Collective roles of molecular chaperones in protein degradation pathways associated with neurodegenerative diseases.Curr Pharm Biotechnol. 2010 Feb;11(2):180-7. doi: 10.2174/138920110790909740. Curr Pharm Biotechnol. 2010. PMID: 20166963 Review.
-
Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications.Apoptosis. 2010 Nov;15(11):1292-311. doi: 10.1007/s10495-010-0466-z. Apoptosis. 2010. PMID: 20131003 Free PMC article. Review.
Cited by
-
Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system.Trends Immunol. 2012 Jul;33(7):357-63. doi: 10.1016/j.it.2012.01.009. Epub 2012 Feb 18. Trends Immunol. 2012. PMID: 22349458 Free PMC article. Review.
-
Measuring protein stability in living zebrafish embryos using fluorescence decay after photoconversion (FDAP).J Vis Exp. 2015 Jan 28;(95):52266. doi: 10.3791/52266. J Vis Exp. 2015. PMID: 25650549 Free PMC article.
-
The physiological role of mitophagy: new insights into phosphorylation events.Int J Cell Biol. 2012;2012:354914. doi: 10.1155/2012/354914. Epub 2012 Mar 7. Int J Cell Biol. 2012. PMID: 22496692 Free PMC article.
-
Role of Autophagy in the Pathogenesis of Diabetes and Therapeutic Potential of Autophagy Modulators in the Treatment of Diabetes and Metabolic Syndrome.J Korean Med Sci. 2022 Sep 26;37(37):e276. doi: 10.3346/jkms.2022.37.e276. J Korean Med Sci. 2022. PMID: 36163475 Free PMC article. Review.
-
Increased dysbindin-1B isoform expression in schizophrenia and its propensity in aggresome formation.Cell Discov. 2015 Nov 10;1:15032. doi: 10.1038/celldisc.2015.32. eCollection 2015. Cell Discov. 2015. PMID: 27462430 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
