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. 2006 Jul;27(21):3995-4002.
doi: 10.1016/j.biomaterials.2006.03.003. Epub 2006 Mar 27.

Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans

Nurit Beyth  1 , Ira Yudovin-Farber, Ran Bahir, Abraham J Domb, Ervin I Weiss
Affiliations

Antibacterial activity of dental composites containing quaternary ammonium polyethylenimine nanoparticles against Streptococcus mutans

Nurit Beyth et al. Biomaterials. 2006 Jul.

Abstract

The antibacterial activity of quaternary ammonium polyethylenimine (PEI) nanoparticles embedded at 1%w/w with clinically used bonding, flowable and hybrid dental composite resins and cured by light polymerization was studied. The antibacterial activity was tested with Streptoccocus mutans by: (i) the agar diffusion test (ADT); (ii) the direct contact test; (iii) bacterial growth in the materials elute; (iv) and scanning electron microscope (SEM). Using the direct contact test, antibacterial activity (p<0.001) was found in all three types of composite resins incorporated with the synthesized nanoparticles. The effect lasted for at least 1 month. SEM demonstrated bacterial debris and no streptococcal chains at 24h of bacterial contact. The addition of 1%w/w of nanoparticles did not affect the flexural modulus and the flexural strength of the dental composite materials. The results indicate that quaternary ammonium PEI nanoparticles immobilized in resin-based materials have a strong antibacterial activity upon contact without leach-out of the nanoparticles and without compromise in mechanical properties.

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