Review
doi: 10.1038/nrm1837.
Critical nodes in signalling pathways: insights into insulin action
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- PMID: 16493415
- DOI: 10.1038/nrm1837
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Review
Critical nodes in signalling pathways: insights into insulin action
Nat Rev Mol Cell Biol.
2006 Feb.
Abstract
Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.
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