Review
doi: 10.1097/01.jnen.0000189834.63951.81.
Mitogenic signal transduction pathways in meningiomas: novel targets for meningioma chemotherapy?
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- PMID: 16319713
- DOI: 10.1097/01.jnen.0000189834.63951.81
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Review
Mitogenic signal transduction pathways in meningiomas: novel targets for meningioma chemotherapy?
J Neuropathol Exp Neurol.
2005 Dec.
Abstract
The roles of growth factor receptors and numerous downstream growth regulatory pathways are of increasing interest in neuro-oncology. These pathways have been extensively studied in gliomas but only recently analyzed in meningiomas. This article reviews current research on the growth factor receptor-Ras-Raf-1-MEK-1-MAPK, PI3K-Akt/PKB, PLC-gamma1-PKC, phospholipase A2-cyclooxygenase, and TGF-beta receptor-Smad pathways that appear to regulate meningioma growth and inhibit apoptosis. Sites along these receptor/kinase cascades that might be targeted by novel therapies are also discussed.
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