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. 2005 Nov 4;19(16):1907-10.
doi: 10.1097/01.aids.0000189849.75699.46.

Inhibition of neutrophil function by the Kaposi's sarcoma-associated herpesvirus vOX2 protein

S A Rahim Rezaee  1 , J Alastair Gracie, Iain B McInnes, David J Blackbourn
Affiliations

Inhibition of neutrophil function by the Kaposi's sarcoma-associated herpesvirus vOX2 protein

S A Rahim Rezaee et al. AIDS. .

Abstract

Kaposi's sarcoma is multifactorial, involving Kaposi's sarcoma-associated herpesvirus (KSHV) infection and immune dysfunction. A KSHV protein (vOX2), fused with the Fc domain of human immunoglobulin G1 to create vOX2:Fc, suppressed neutrophil oxidative burst and inhibited the production of pro-inflammatory chemokines (IL-8 and monocyte chemoattractant protein 1) by monocyte/macrophage cells. vOX2:Fc suppressed the acute inflammatory response in mice in which neutrophil-mediated inflammation was induced by carrageenan. The data suggest that vOX2 can contribute to immune dysfunction and could have anti-inflammatory therapeutic potential.

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