Review
doi: 10.1089/vim.2005.18.457.
Herpes simplex virus and toll-like receptors
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- PMID: 16212524
- DOI: 10.1089/vim.2005.18.457
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Review
Herpes simplex virus and toll-like receptors
Viral Immunol.
2005.
Abstract
The earliest interactions between viruses and host cells are critical to determining the outcome of infections. The interactions between a virus and its host cells that lead to the production of inflammatory cytokines are essential to the development of T cells and antibodies that provide long-term defense against the invaders. At the same time, however, these same cytokines (or sometimes other mediators or chemokines) stimulate inflammation, which may lead to localized tissue damage and/or systemic circulatory collapse and death. This review focuses on the interaction between Toll-like receptors, a critical component of the innate immune system of mammals, and their role in herpes simplex pathogenesis and immunity.
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