doi: 10.1016/j.febslet.2005.06.008.
Transfer of beta subunit regulation from high to low voltage-gated Ca2+ channels
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- PMID: 15987636
- DOI: 10.1016/j.febslet.2005.06.008
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Transfer of beta subunit regulation from high to low voltage-gated Ca2+ channels
FEBS Lett.
.
Free article
Abstract
High voltage-activated Ca(2+) channel expression and gating is controlled by their beta subunits. Although the sites of interaction are known at the atomic level, how beta modulates gating remains to be determined. Using a chimeric approach, beta subunit regulation was conferred to a low voltage-activated channel. Regulation was dependent on a rigid linker connecting the alpha(1) interaction domain to IS6. Chimeric channels also revealed a role for IS6 in channel gating. Taken together, these results support a direct coupling model where beta subunits alter movements in IS6 that occur as the channel transits between closed, open, and inactivated states.
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